Showing metabocard for Dechloroisochromophilone II (MMDBc0060760)
Microbial
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| Version | 2.0 | ||||||||||||
| Status | Detected and Quantified | ||||||||||||
| Creation Date | 2025-10-02 22:46:33 UTC | ||||||||||||
| Update Date | 2025-10-08 21:35:19 UTC | ||||||||||||
| Metabolite ID | MMDBc0060760 | ||||||||||||
| Metabolite Identification | |||||||||||||
| Common Name | Dechloroisochromophilone II | ||||||||||||
| Description | Dechloroisochromophilone II is a member of the azaphilone chemical class, characterized by its unique isochromophilone structure. This compound is derived from the fermentation of the fungus Penicillium multicolor FO-2338, which produces various isochromophilones, including dechloroisochromophilone III and isorotiorin. The chemical structure of dechloroisochromophilone II features a chromone-like core with specific substitutions that contribute to its biological activity. Notably, azaphilones such as dechloroisochromophilone II have been shown to inhibit the binding of gp120 to CD4, a critical interaction in the HIV entry pathway. This inhibition suggests potential applications in antiviral research, particularly in developing strategies to block HIV infection. The synthesis and isolation of dechloroisochromophilone II and related compounds from the culture broth of Penicillium multicolor highlight the diverse metabolic capabilities of this organism and its potential as a source of bioactive natural products (PMID: [insert PMID here]). | ||||||||||||
| Structure |  | ||||||||||||
| Synonyms | Not Available | ||||||||||||
| Molecular Formula | C22H28O4 | ||||||||||||
| Average Mass | 356.462 | ||||||||||||
| Monoisotopic Mass | 356.198759382 | ||||||||||||
| IUPAC Name | Not Available | ||||||||||||
| Traditional Name | Not Available | ||||||||||||
| CAS Registry Number | Not Available | ||||||||||||
| SMILES | Not Available | ||||||||||||
| InChI Identifier | Not Available | ||||||||||||
| InChI Key | WQZDWHLJAFBAQK-WESQECEQNA-N | ||||||||||||
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| State | Not Available | ||||||||||||
| Predicted Properties | Not Available | ||||||||||||
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| Cellular Locations | Not Available | ||||||||||||
| Biospecimen Locations | Not Available | ||||||||||||
| Tissue Locations | Not Available | ||||||||||||
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| Pathways | This table shows at most 5 pathways. For the full list of associated pathways: See All Associated Bacterial Pathways
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Reactions This table shows at most 20 reactions. For the full list of associated reactions: See All Associated Reactions
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| External Links | |||||||||||||
| CMMC Knowledgebase | WQZDWHLJAFBAQK-WESQECEQSA-N | ||||||||||||
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| Synthesis Reference | Not Available | ||||||||||||
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