Showing metabocard for Ethynylserine (MMDBc0060769)
Microbial
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| Version | 1.0 | ||||||||||||
| Status | Detected and Quantified | ||||||||||||
| Creation Date | 2025-10-02 22:53:55 UTC | ||||||||||||
| Update Date | 2025-10-08 21:35:19 UTC | ||||||||||||
| Metabolite ID | MMDBc0060769 | ||||||||||||
| Metabolite Identification | |||||||||||||
| Common Name | Ethynylserine | ||||||||||||
| Description | Ethynylserine is a non-canonical amino acid belonging to the class of alkyne-containing amino acids. Its chemical structure features a terminal alkyne group, which is critical for its function in various biosynthetic pathways. The biosynthesis of L-β-ethynylserine involves a pyridoxal phosphate-dependent enzyme, BesB, which catalyzes the formation of L-propargylglycine from a vinyl halide precursor, 4-chloro-L-allylglycine (PMID:40562852 ). Additionally, the compound is utilized in innovative labeling techniques, such as the THRONCAT method, which allows for the efficient tagging of nascent proteins in growth media (PMID:37291115 ). Ethynylserine also plays a role in the biosynthesis of dipeptides, including γ-l-glutamyl-l-β-ethynylserine, through the expression of enzymes like halogenase, oxidase, lyase, ligase, and hydroxylase (PMID:37040607 ). Furthermore, it acts as an antimetabolite of L-threonine, highlighting its potential impact on metabolic pathways (PMID:3082841 ). Overall, ethynylserine's unique structure and involvement in various enzymatic processes underscore its significance in both chemistry and biology. | ||||||||||||
| Structure |  | ||||||||||||
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| Molecular Formula | C5H7NO3 | ||||||||||||
| Average Mass | 129.115 | ||||||||||||
| Monoisotopic Mass | 129.042593089 | ||||||||||||
| IUPAC Name | Not Available | ||||||||||||
| Traditional Name | Not Available | ||||||||||||
| CAS Registry Number | Not Available | ||||||||||||
| SMILES | Not Available | ||||||||||||
| InChI Identifier | Not Available | ||||||||||||
| InChI Key | RBWXRFBKVDBXEG-DMTCNVIQSA-N | ||||||||||||
| Chemical Taxonomy | |||||||||||||
| Description | Belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom. | ||||||||||||
| Kingdom | Organic compounds | ||||||||||||
| Super Class | Organic acids and derivatives | ||||||||||||
| Class | Carboxylic acids and derivatives | ||||||||||||
| Sub Class | Amino acids, peptides, and analogues | ||||||||||||
| Direct Parent | L-alpha-amino acids | ||||||||||||
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| Molecular Framework | Aliphatic acyclic compounds | ||||||||||||
| External Descriptors | Not Available | ||||||||||||
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| State | Not Available | ||||||||||||
| Predicted Properties | Not Available | ||||||||||||
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| Cellular Locations | Not Available | ||||||||||||
| Biospecimen Locations | Not Available | ||||||||||||
| Tissue Locations | Not Available | ||||||||||||
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| Pathways | This table shows at most 5 pathways. For the full list of associated pathways: See All Associated Bacterial Pathways
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Reactions This table shows at most 20 reactions. For the full list of associated reactions: See All Associated Reactions
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| HMDB ID | Not Available | ||||||||||||
| DrugBank ID | Not Available | ||||||||||||
| Phenol Explorer Compound ID | Not Available | ||||||||||||
| FooDB ID | Not Available | ||||||||||||
| KNApSAcK ID | Not Available | ||||||||||||
| Chemspider ID | Not Available | ||||||||||||
| KEGG Compound ID | Not Available | ||||||||||||
| BioCyc ID | Not Available | ||||||||||||
| BiGG ID | Not Available | ||||||||||||
| Wikipedia Link | Not Available | ||||||||||||
| METLIN ID | Not Available | ||||||||||||
| PubChem Compound | 127838 | ||||||||||||
| PDB ID | Not Available | ||||||||||||
| ChEBI ID | Not Available | ||||||||||||
| Food Biomarker Ontology | Not Available | ||||||||||||
| CMMC Knowledgebase | Not Available | ||||||||||||
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| Synthesis Reference | Not Available | ||||||||||||
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