Microbial
Record Information
Version1.0
StatusDetected and Quantified
Creation Date2025-10-02 22:57:10 UTC
Update Date2025-10-08 21:35:20 UTC
Metabolite IDMMDBc0060773
Metabolite Identification
Common Nameisorotiorin
Descriptionisorotiorin is a member of the azaphilone chemical class, characterized by its unique bicyclic structure that features a fused isoquinoline and phenolic moiety. This compound is synthesized through polyketide biosynthetic pathways, specifically involving highly reducing and non-reducing polyketide synthases (PKS), as evidenced by the knockout studies of the sclA and sclI genes, which demonstrated a loss of mycelial pigmentation and halted the production of several sclerotiorin-like metabolites, including isorotiorin (PMID:36708387 ). Isorotiorin, along with other azaphilones, has been isolated from the culture broth of Penicillium multicolor FO-2338, a known producer of isochromophilones that inhibit gp120-CD4 binding (PMID:36708387 ). This highlights its role in the complex biosynthetic landscape of fungal metabolites and suggests potential pathways for further exploration in both chemical and biological contexts.
Structure
SynonymsNot Available
Molecular FormulaC23H28O5
Average Mass384.472
Monoisotopic Mass384.193674002
IUPAC NameNot Available
Traditional NameNot Available
CAS Registry NumberNot Available
SMILESNot Available
InChI Identifier
Not Available
InChI KeyMUZXNENCXNWLKC-SRGKMVLISA-N