Showing metabocard for Nancimycin (MMDBc0060785)
Microbial
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| Version | 1.0 | ||||||||||||
| Status | Detected and Quantified | ||||||||||||
| Creation Date | 2025-10-02 23:06:52 UTC | ||||||||||||
| Update Date | 2025-10-08 21:35:20 UTC | ||||||||||||
| Metabolite ID | MMDBc0060785 | ||||||||||||
| Metabolite Identification | |||||||||||||
| Common Name | Nancimycin | ||||||||||||
| Description | Nancimycin is a member of the rifamycin class of antibiotics, characterized by its complex chemical structure featuring a naphthacene core linked to a hydroxyl group and various other functional groups. The chemical formula of nancimycin includes multiple chiral centers, contributing to its unique stereochemistry. Nancimycin is primarily known for its role in inhibiting bacterial RNA synthesis by binding to the RNA polymerase enzyme, thereby obstructing the transcription process. This mechanism is crucial in its antibacterial activity, as it effectively halts the growth of susceptible bacteria. Additionally, nancimycin's biosynthetic pathways involve the enzymatic conversion of precursors derived from polyketide synthases, leading to the production of this potent antibiotic. Its identification as rifamycin B highlights its significance within the broader context of antibiotic development and its structural relationship to other compounds in the rifamycin family (PMID:6072901 ). Overall, nancimycin exemplifies the intricate interplay between chemical structure and biological function, showcasing the importance of natural products in the fight against bacterial infections. | ||||||||||||
| Structure |  | ||||||||||||
| Synonyms | Not Available | ||||||||||||
| Molecular Formula | C39H49NO14 | ||||||||||||
| Average Mass | 755.814 | ||||||||||||
| Monoisotopic Mass | 755.315305262 | ||||||||||||
| IUPAC Name | Not Available | ||||||||||||
| Traditional Name | Not Available | ||||||||||||
| CAS Registry Number | Not Available | ||||||||||||
| SMILES | Not Available | ||||||||||||
| InChI Identifier | Not Available | ||||||||||||
| InChI Key | SQTCRTQCPJICLD-UHFFFAOYNA-N | ||||||||||||
| Chemical Taxonomy | |||||||||||||
| Functional Ontology | |||||||||||||
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| Physical Properties | |||||||||||||
| State | Not Available | ||||||||||||
| Predicted Properties | Not Available | ||||||||||||
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| Cellular Locations | Not Available | ||||||||||||
| Biospecimen Locations | Not Available | ||||||||||||
| Tissue Locations | Not Available | ||||||||||||
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| Pathways |
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| Microbial Pathways | |||||||||||||
| Pathways | This table shows at most 5 pathways. For the full list of associated pathways: See All Associated Bacterial Pathways
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| Metabolic Reactions | |||||||||||||
Reactions This table shows at most 20 reactions. For the full list of associated reactions: See All Associated Reactions
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| Host Biospecimen and Location | |||||||||||||
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| External Links | |||||||||||||
| CMMC Knowledgebase | SQTCRTQCPJICLD-UHFFFAOYSA-N | ||||||||||||
| References | |||||||||||||
| Synthesis Reference | Not Available | ||||||||||||
| General References |
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