Showing metabocard for Pyrromycin (MMDBc0060809)
Microbial
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| Version | 1.0 | ||||||||||||
| Status | Detected and Quantified | ||||||||||||
| Creation Date | 2025-10-02 23:26:09 UTC | ||||||||||||
| Update Date | 2025-10-08 21:35:22 UTC | ||||||||||||
| Metabolite ID | MMDBc0060809 | ||||||||||||
| Metabolite Identification | |||||||||||||
| Common Name | Pyrromycin | ||||||||||||
| Description | Pyrromycin is a member of the anthracycline chemical class, characterized by a tetracyclic ring structure that is typical of this group. Its chemical structure features a glycosidic bond, which is crucial for its biological activity. Pyrromycin has been identified as a metabolite produced by certain microbial isolates, alongside other compounds like doxorubicinol and erythromycin (PMID:29720968 ). In various studies, pyrromycin has been shown to interact with DNA methyltransferases (DNMTs), indicating its potential role in epigenetic regulation (PMID:26099696 ). High-throughput screening has highlighted pyrromycin as an upregulator of ABCA1 expression, suggesting involvement in lipid metabolism pathways (PMID:18594022 ). Additionally, its growth-inhibitory effects have been compared with other anthracyclines in both resistant and wild-type cell lines, revealing its potency against cancer cells (PMID:8422694 ). Furthermore, pyrromycin has been implicated in stimulating erythroid differentiation and hemoglobin synthesis in specific cell lines, distinguishing it from other anthracyclines that do not exhibit this effect (PMID:2020200 ). Overall, pyrromycin's unique structural features and biological activities contribute to its significance in the field of medicinal chemistry. | ||||||||||||
| Structure |  | ||||||||||||
| Synonyms | Not Available | ||||||||||||
| Molecular Formula | C30H35NO11 | ||||||||||||
| Average Mass | 585.606 | ||||||||||||
| Monoisotopic Mass | 585.221010951 | ||||||||||||
| IUPAC Name | Not Available | ||||||||||||
| Traditional Name | Not Available | ||||||||||||
| CAS Registry Number | Not Available | ||||||||||||
| SMILES | Not Available | ||||||||||||
| InChI Identifier | Not Available | ||||||||||||
| InChI Key | ZJBMQVPEJHVSQA-OCYVVMCSSA-N | ||||||||||||
| Chemical Taxonomy | |||||||||||||
| Description | Belongs to the class of organic compounds known as anthracyclines. These are polyketides containing a tetracenequinone ring structure with a sugar attached by glycosidic linkage. | ||||||||||||
| Kingdom | Organic compounds | ||||||||||||
| Super Class | Phenylpropanoids and polyketides | ||||||||||||
| Class | Anthracyclines | ||||||||||||
| Sub Class | Not Available | ||||||||||||
| Direct Parent | Anthracyclines | ||||||||||||
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| Substituents |
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| Molecular Framework | Aromatic heteropolycyclic compounds | ||||||||||||
| External Descriptors | Not Available | ||||||||||||
| Functional Ontology | |||||||||||||
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| Physical Properties | |||||||||||||
| State | Not Available | ||||||||||||
| Predicted Properties | Not Available | ||||||||||||
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| Cellular Locations | Not Available | ||||||||||||
| Biospecimen Locations | Not Available | ||||||||||||
| Tissue Locations | Not Available | ||||||||||||
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| Pathways |
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| Microbial Pathways | |||||||||||||
| Pathways | This table shows at most 5 pathways. For the full list of associated pathways: See All Associated Bacterial Pathways
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| Metabolic Reactions | |||||||||||||
Reactions This table shows at most 20 reactions. For the full list of associated reactions: See All Associated Reactions
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| External Links | |||||||||||||
| HMDB ID | Not Available | ||||||||||||
| DrugBank ID | Not Available | ||||||||||||
| Phenol Explorer Compound ID | Not Available | ||||||||||||
| FooDB ID | Not Available | ||||||||||||
| KNApSAcK ID | Not Available | ||||||||||||
| Chemspider ID | Not Available | ||||||||||||
| KEGG Compound ID | Not Available | ||||||||||||
| BioCyc ID | Not Available | ||||||||||||
| BiGG ID | Not Available | ||||||||||||
| Wikipedia Link | Not Available | ||||||||||||
| METLIN ID | Not Available | ||||||||||||
| PubChem Compound | 196990 | ||||||||||||
| PDB ID | Not Available | ||||||||||||
| ChEBI ID | Not Available | ||||||||||||
| Food Biomarker Ontology | Not Available | ||||||||||||
| CMMC Knowledgebase | ZJBMQVPEJHVSQA-OCYVVMCSSA-N | ||||||||||||
| References | |||||||||||||
| Synthesis Reference | Not Available | ||||||||||||
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