Showing metabocard for Sclerotioramine (MMDBc0060810)
Microbial
| Record Information | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Version | 2.0 | ||||||||||||
| Status | Detected and Quantified | ||||||||||||
| Creation Date | 2025-10-02 23:26:57 UTC | ||||||||||||
| Update Date | 2025-10-08 21:35:22 UTC | ||||||||||||
| Metabolite ID | MMDBc0060810 | ||||||||||||
| Metabolite Identification | |||||||||||||
| Common Name | Sclerotioramine | ||||||||||||
| Description | Sclerotioramine is a chlorinated azaphilone alkaloid metabolite produced by certain fungi. Its chemical structure, characterized by a unique arrangement of carbon, nitrogen, and chlorine atoms, was elucidated using advanced analytical techniques such as NMR, LC-MS/MS, and HPLC-PDA (PMID:38514498 ). This compound exhibits significant antioxidant activity, with ORAC values indicating that its antioxidant capacity is more than twice that of its analog, sclerotiorin (PMID:38514498 ). Additionally, sclerotioramine has demonstrated notable antibacterial properties (PMID:38257261 ). It has been isolated alongside other related compounds from the fermentation products of various fungal species, including Penicillium sclerotiorin and ACD-5 in brown rice medium, which were guided by bioactivity assessments and mass spectrometry (PMID:37206330 , PMID:34498957 ). Furthermore, sclerotioramine derivatives have been synthesized, showcasing potential antifouling activities (PMID:28688034 ). The pathways involved in the biosynthesis of sclerotioramine and its derivatives contribute to its biological roles, although the specific metabolic pathways remain to be fully elucidated. | ||||||||||||
| Structure |  | ||||||||||||
| Synonyms | Not Available | ||||||||||||
| Molecular Formula | C21H24ClNO4 | ||||||||||||
| Average Mass | 389.88 | ||||||||||||
| Monoisotopic Mass | 389.139386 | ||||||||||||
| IUPAC Name | Not Available | ||||||||||||
| Traditional Name | Not Available | ||||||||||||
| CAS Registry Number | Not Available | ||||||||||||
| SMILES | Not Available | ||||||||||||
| InChI Identifier | Not Available | ||||||||||||
| InChI Key | DOUKEKLEUAGITQ-NJHPPEEMNA-N | ||||||||||||
| Chemical Taxonomy | |||||||||||||
| Functional Ontology | |||||||||||||
| Not Available | |||||||||||||
| Physical Properties | |||||||||||||
| State | Not Available | ||||||||||||
| Predicted Properties | Not Available | ||||||||||||
| Spectra | |||||||||||||
| Not Available | |||||||||||||
| Biological Properties | |||||||||||||
| Cellular Locations | Not Available | ||||||||||||
| Biospecimen Locations | Not Available | ||||||||||||
| Tissue Locations | Not Available | ||||||||||||
| Associated OMIM IDs | |||||||||||||
| Human Proteins and Enzymes | |||||||||||||
| |||||||||||||
| Human Pathways | |||||||||||||
| Pathways |
| ||||||||||||
| Microbial Pathways | |||||||||||||
| Pathways | This table shows at most 5 pathways. For the full list of associated pathways: See All Associated Bacterial Pathways
| ||||||||||||
| Metabolic Reactions | |||||||||||||
Reactions This table shows at most 20 reactions. For the full list of associated reactions: See All Associated Reactions
| |||||||||||||
| Health Effects and Bioactivity | |||||||||||||
| |||||||||||||
| Microbial Sources | |||||||||||||
| |||||||||||||
| Exposure Sources | |||||||||||||
| Other Exposures |
| ||||||||||||
| Host Biospecimen and Location | |||||||||||||
| |||||||||||||
| External Links | |||||||||||||
| CMMC Knowledgebase | DOUKEKLEUAGITQ-NJHPPEEMSA-N | ||||||||||||
| References | |||||||||||||
| Synthesis Reference | Not Available | ||||||||||||
| General References |
| ||||||||||||
