Showing metabocard for Sclerotiorin (MMDBc0060811)
Microbial
| Record Information | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Version | 2.0 | ||||||||||||
| Status | Detected and Quantified | ||||||||||||
| Creation Date | 2025-10-02 23:27:44 UTC | ||||||||||||
| Update Date | 2025-10-08 21:35:23 UTC | ||||||||||||
| Metabolite ID | MMDBc0060811 | ||||||||||||
| Metabolite Identification | |||||||||||||
| Common Name | Sclerotiorin | ||||||||||||
| Description | Sclerotiorin is a member of the azaphilone chemical class, characterized by a unique pyranoquinone core structure. This metabolite has been isolated from various fungal species, including the marine-derived fungus Microsphaeropsis arundinis, where it was identified alongside other sclerotiorin-type azaphilones featuring rare γ-lactone or tetrahydrofuran fragments at the C-3 position (PMID:40168493 ). The biosynthetic pathways of these compounds have been elucidated, revealing the role of the LutB transcription factor in overexpressing pathway-specific genes to produce new sclerotiorin-type azaphilones (PMID:38962874 ). Additionally, a LutC-LutD binary oxidoreductase system has been discovered, contributing to the understanding of the basic biosynthetic pathway of sclerotiorin-type azaphilones (PMID:38962874 ). Sclerotiorin also exhibits antioxidant properties, with its activity measured against that of sclerotioramine, which demonstrated significantly higher antioxidant capacity (PMID:38514498 ). The compound has been identified in various fungal species, including Penicillium sclerotiorum and Clonostachys rosea, highlighting its widespread occurrence in nature (PMID:38051942 ). | ||||||||||||
| Structure |  | ||||||||||||
| Synonyms | Not Available | ||||||||||||
| Molecular Formula | C22H26O5 | ||||||||||||
| Average Mass | 370.445 | ||||||||||||
| Monoisotopic Mass | 370.178023937 | ||||||||||||
| IUPAC Name | Not Available | ||||||||||||
| Traditional Name | Not Available | ||||||||||||
| CAS Registry Number | Not Available | ||||||||||||
| SMILES | Not Available | ||||||||||||
| InChI Identifier | Not Available | ||||||||||||
| InChI Key | CZPXLTLKPOJRMB-QWOULBPOSA-N | ||||||||||||
| Chemical Taxonomy | |||||||||||||
| Functional Ontology | |||||||||||||
| Not Available | |||||||||||||
| Physical Properties | |||||||||||||
| State | Not Available | ||||||||||||
| Predicted Properties | Not Available | ||||||||||||
| Spectra | |||||||||||||
| Not Available | |||||||||||||
| Chromatographic Retention Times and Retention Indices | |||||||||||||
| Retention Times | Not Available | ||||||||||||
| Retention Indices | Not Available | ||||||||||||
| Biological Properties | |||||||||||||
| Cellular Locations | Not Available | ||||||||||||
| Biospecimen Locations | Not Available | ||||||||||||
| Tissue Locations | Not Available | ||||||||||||
| Associated OMIM IDs | |||||||||||||
| Human Proteins and Enzymes | |||||||||||||
| |||||||||||||
| Human Pathways | |||||||||||||
| Pathways |
| ||||||||||||
| Microbial Pathways | |||||||||||||
| Pathways | Not Available | ||||||||||||
| Metabolic Reactions | |||||||||||||
Reactions This table shows at most 20 reactions. For the full list of associated reactions: See All Associated Reactions
| |||||||||||||
| Health Effects and Bioactivity | |||||||||||||
| |||||||||||||
| Microbial Sources | |||||||||||||
| |||||||||||||
| Exposure Sources | |||||||||||||
| Other Exposures |
| ||||||||||||
| Host Biospecimen and Location | |||||||||||||
| |||||||||||||
| External Links | |||||||||||||
| CMMC Knowledgebase | CZPXLTLKPOJRMB-QWOULBPOSA-N | ||||||||||||
| General References | |||||||||||||
| |||||||||||||
