Showing metabocard for Siamycin (MMDBc0060815)
Microbial
| Record Information | |||||||||||||||||||||
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| Version | 1.0 | ||||||||||||||||||||
| Status | Detected and Quantified | ||||||||||||||||||||
| Creation Date | 2025-10-02 23:30:58 UTC | ||||||||||||||||||||
| Update Date | 2025-10-08 21:35:23 UTC | ||||||||||||||||||||
| Metabolite ID | MMDBc0060815 | ||||||||||||||||||||
| Metabolite Identification | |||||||||||||||||||||
| Common Name | Siamycin | ||||||||||||||||||||
| Description | Siamycin is a lasso peptide, a class of ribosomally synthesized and post-translationally modified peptides characterized by their unique topological structure, which includes a loop and a tail that is threaded through the loop. Chemically, siamycin-I has been shown to interact specifically with lipid II, a crucial component of bacterial cell wall biosynthesis, effectively targeting the Gram-positive cell surface and inhibiting peptidoglycan synthesis (PMID:31026131 ). This interaction disrupts the integrity of the bacterial cell wall, leading to cell lysis and death, particularly in vancomycin-resistant pathogens (PMID:40034853 ). Siamycin's mechanism of action is further underscored by its ability to restore vancomycin susceptibility in resistant strains of Enterococcus and Staphylococcus aureus, highlighting its potential therapeutic applications (PMID:40034853 ). Additionally, siamycin is associated with unique biosynthetic gene clusters that may encode novel compounds with significant biological activity, including cancer cell growth inhibition (PMID:39417076 ). Its structural similarities to other lasso peptides, such as specialicin, suggest a conserved mechanism among this class (PMID:30448257 ), making siamycin a noteworthy subject of study in the development of new antimicrobial strategies. | ||||||||||||||||||||
| Structure |  | ||||||||||||||||||||
| Synonyms | Not Available | ||||||||||||||||||||
| Molecular Formula | C97H131N23O26S4 | ||||||||||||||||||||
| Average Mass | 2163.49 | ||||||||||||||||||||
| Monoisotopic Mass | 2161.851846126 | ||||||||||||||||||||
| IUPAC Name | Not Available | ||||||||||||||||||||
| Traditional Name | Not Available | ||||||||||||||||||||
| CAS Registry Number | Not Available | ||||||||||||||||||||
| SMILES | Not Available | ||||||||||||||||||||
| InChI Identifier | Not Available | ||||||||||||||||||||
| InChI Key | TXYRKTDGDMHVHR-UHFFFAOYNA-N | ||||||||||||||||||||
| Chemical Taxonomy | |||||||||||||||||||||
| Functional Ontology | |||||||||||||||||||||
| Not Available | |||||||||||||||||||||
| Physical Properties | |||||||||||||||||||||
| State | Not Available | ||||||||||||||||||||
| Predicted Properties | Not Available | ||||||||||||||||||||
| Spectra | |||||||||||||||||||||
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| Cellular Locations | Not Available | ||||||||||||||||||||
| Biospecimen Locations | Not Available | ||||||||||||||||||||
| Tissue Locations | Not Available | ||||||||||||||||||||
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| Pathways |
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| Pathways | This table shows at most 5 pathways. For the full list of associated pathways: See All Associated Bacterial Pathways
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Reactions This table shows at most 20 reactions. For the full list of associated reactions: See All Associated Reactions
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| External Links | |||||||||||||||||||||
| CMMC Knowledgebase | TXYRKTDGDMHVHR-UHFFFAOYSA-N | ||||||||||||||||||||
| References | |||||||||||||||||||||
| Synthesis Reference | Not Available | ||||||||||||||||||||
| General References |
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