Showing metabocard for Streptovaricins (MMDBc0060817)
Microbial
| Record Information | |||||||||||||
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| Version | 1.0 | ||||||||||||
| Status | Detected and Quantified | ||||||||||||
| Creation Date | 2025-10-02 23:32:37 UTC | ||||||||||||
| Update Date | 2025-10-08 21:35:23 UTC | ||||||||||||
| Metabolite ID | MMDBc0060817 | ||||||||||||
| Metabolite Identification | |||||||||||||
| Common Name | Streptovaricins | ||||||||||||
| Description | Streptovaricins is a member of the chemical class of polyketides, specifically related to the rifamycins. Its chemical structure features a complex arrangement that includes a methylenedioxy bridge (MDB) and various functional groups that contribute to its bioactivity. The biosynthesis of streptovaricins involves cytochrome P450 enzymes, particularly StvP2, which catalyzes the formation of the MDB, a crucial moiety linked to its antibacterial properties (PMID:32908132 ). Additionally, the formation of streptovaricins requires C6-O-methylation and C4-O-acetylation as prerequisites for MDB formation (PMID:32908132 ). Streptovaricins exhibit significant antibacterial activity, particularly against methicillin-resistant Staphylococcus aureus (MRSA), with structure-activity relationships indicating that hydroxyl groups at specific positions, such as C-8 and C-28, enhance this activity (PMID:33550879 , PMID:28858479 ). The exploration of these compounds has led to the identification of derivatives with improved antibacterial properties, highlighting their potential in combating resistant bacterial strains (PMID:28858479 ). Despite the discovery of heterocyclic ring-fused analogs, such as ansavaricin J and E, their antibacterial efficacy remains limited (PMID:32492242 ). | ||||||||||||
| Structure |  | ||||||||||||
| Synonyms | Not Available | ||||||||||||
| Molecular Formula | C40H51NO14 | ||||||||||||
| Average Mass | 769.841 | ||||||||||||
| Monoisotopic Mass | 769.330955326 | ||||||||||||
| IUPAC Name | Not Available | ||||||||||||
| Traditional Name | Not Available | ||||||||||||
| CAS Registry Number | Not Available | ||||||||||||
| SMILES | Not Available | ||||||||||||
| InChI Identifier | Not Available | ||||||||||||
| InChI Key | JDECNKBYILMOLE-UHFFFAOYNA-N | ||||||||||||
| Chemical Taxonomy | |||||||||||||
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| Physical Properties | |||||||||||||
| State | Not Available | ||||||||||||
| Predicted Properties | Not Available | ||||||||||||
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| Cellular Locations | Not Available | ||||||||||||
| Biospecimen Locations | Not Available | ||||||||||||
| Tissue Locations | Not Available | ||||||||||||
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| Pathways |
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| Pathways | This table shows at most 5 pathways. For the full list of associated pathways: See All Associated Bacterial Pathways
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| Metabolic Reactions | |||||||||||||
Reactions This table shows at most 20 reactions. For the full list of associated reactions: See All Associated Reactions
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| Health Effects and Bioactivity | |||||||||||||
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| External Links | |||||||||||||
| CMMC Knowledgebase | JDECNKBYILMOLE-UHFFFAOYSA-N | ||||||||||||
| References | |||||||||||||
| Synthesis Reference | Not Available | ||||||||||||
| General References |
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