| Description | Granulibacter bethesdensis is a gram-negative, rod-shaped microbe that thrives in mesophilic temperatures, categorizing it as a chemoheterotroph, and can be found in various body sites, including the respiratory tract, skin, and mucous membranes, across different species. As a chemoheterotroph, Granulibacter bethesdensis relies on organic compounds for energy and carbon, obtaining these nutrients from its environment. Its gram-negative cell wall structure allows it to maintain a stable internal environment, despite changes in external conditions. The rod-shaped morphology of Granulibacter bethesdensis enables it to move efficiently through its surroundings, utilizing its flagella for motility. As a mesophilic microbe, Granulibacter bethesdensis prefers moderate temperatures, typically between 20-45°C, which is optimal for its growth and metabolic processes. It is an obligate aerobe, requiring oxygen to survive and carry out its metabolic functions, which involves the breakdown of organic compounds to produce energy.Granulibacter bethesdensis has been identified as an opportunistic pathogen, particularly in individuals with compromised immune systems, such as those with chronic granulomatous disease. Its ability to infect various body sites makes it a significant concern for immunocompromised patients. The microbe's presence in different species highlights its adaptability and potential for zoonotic transmission. Research on Granulibacter bethesdensis has led to a greater understanding of its role in human disease, and its unique characteristics have made it a subject of study in the fields of microbiology and immunology. Granulibacter bethesdensis was first isolated from a patient with chronic granulomatous disease, and since then, it has been recognized as a cause of infection in individuals with this condition, emphasizing the importance of continued research into its biology and pathogenesis. |
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