| Description | Eggerthella sp. CAG:298 is a Gram-positive bacterium characterized by its unique arrangement in chains and its lack of sporulation. This microbe is part of the diverse intestinal microflora found in animals, contributing to the complex ecosystem of the gut. As a chemoheterotroph, Eggerthella sp. CAG:298 relies on organic compounds from its environment for energy and growth, showcasing its adaptability to the nutrient-rich conditions of the intestinal tract. One of the notable metabolic activities of Eggerthella sp. CAG:298 is its bile acid 12α-hydroxysteroid dehydrogenase (12α-Hsdh) activity, which plays a crucial role in the biotransformation of bile acids. This process can influence host lipid metabolism and gut health, suggesting potential implications in conditions such as hyperlipidemia and obesity. Additionally, the bacterium is involved in the synthesis of gamma-aminobutyric acid (GABA), a neurotransmitter known for its calming effects on the nervous system. This synthesis can impact the gut-brain axis, highlighting the potential influence of microbiota on mental health and emotional well-being. The presence of Eggerthella sp. CAG:298 in the intestinal ecosystem is not just a reflection of its metabolic capabilities, but it also underscores the intricate relationships between gut microbiota, host physiology, and overall health. Its ability to modulate bile acid and neurotransmitter levels suggests that this microbe may play a significant role in maintaining gut homeostasis and influencing broader physiological processes. |
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