| Description | Allisonella histaminiformans is a notable member of the gut microbiota, recognized for its unique metabolic capabilities. This bacterium is a non-sporulating, fermentative microbe that plays a significant role in the decarboxylation of histidine, leading to the production of histamine. As a chemoheterotroph, A. histaminiformans utilizes organic compounds as its energy source, allowing it to thrive in the anaerobic environment of the host gut. One of the most intriguing aspects of A. histaminiformans is its ability to produce histamine, a biogenic amine that can have various biological effects, including modulation of immune responses and influence on gut motility. This production can affect the overall gut microbial community and host metabolism, highlighting the intricate interplay between gut microbiota and host physiology.A. histaminiformans has been identified in the gastrointestinal tracts of different hosts, including humans, where it may contribute to health or disease states depending on its abundance and activity. The presence of this microbe is often associated with conditions where histamine plays a crucial role, such as allergies or gastrointestinal disorders. The ecological significance of A. histaminiformans extends beyond mere histamine production; it underscores the importance of microbial metabolism in shaping host health. By participating in histidine degradation, this microbe may influence nutrient availability and microbial diversity within the gut, revealing the complex interdependencies that exist within the gastrointestinal ecosystem. As such, A. histaminiformans exemplifies the dynamic relationship between microorganisms and their hosts, with potential implications for understanding gut health and disease. |
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