MiMeDB: Showing metabocard for 2,5-Diketo-D-gluconate (MMDBc0029780)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-17 23:41:22 UTC

Update Date

2022-08-31 17:16:54 UTC

Metabolite ID

MMDBc0029780

Metabolite Identification

Common Name

2,5-Diketo-D-gluconate

Description

2,5-Diketo-D-gluconate is an intermediate in the synthesis of ascorbic acid. It is a substrate for the enzyme 2,5-diketo-D-gluconic acid reductase B. This enzyme catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG) with the following reaction: 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH.

Structure

MOL SDF PDB SMILES InChI


  Mrv0541 08131209042D          

 15 14  0  0  0  0            999 V2000
    1.7605    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4750    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895    1.8414    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.9039    1.4289    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.6184    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0461    1.4289    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4750    0.6039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895    2.6664    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9039    0.6039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6184    2.6664    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0474    1.8414    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.3329    0.6039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895    1.0164    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9039    2.2539    0.0000 H   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  0  0  0  0
  3  2  1  0  0  0  0
  4  3  1  0  0  0  0
  5  4  1  0  0  0  0
  6  5  1  0  0  0  0
  7  1  1  0  0  0  0
  8  2  2  0  0  0  0
  3  9  1  6  0  0  0
  4 10  1  6  0  0  0
 11  5  2  0  0  0  0
 12  6  1  0  0  0  0
 13  6  2  0  0  0  0
  3 14  1  6  0  0  0
  4 15  1  6  0  0  0
M  CHG  1  12  -1
M  END
> <DATABASE_ID>
MMDBc0029780

> <DATABASE_NAME>
MIME

> <SMILES>
[H][C@@](O)(C(=O)CO)[C@]([H])(O)C(=O)C([O-])=O

> <INCHI_IDENTIFIER>
InChI=1S/C6H8O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h3-4,7,9-10H,1H2,(H,12,13)/p-1/t3-,4+/m1/s1

> <INCHI_KEY>
RXMWXENJQAINCC-DMTCNVIQSA-M

> <FORMULA>
C6H7O7

> <MOLECULAR_WEIGHT>
191.1156

> <EXACT_MASS>
191.019177578

> <JCHEM_ACCEPTOR_COUNT>
7

> <JCHEM_AVERAGE_POLARIZABILITY>
15.10513295774124

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
-1

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(3S,4S)-3,4,6-trihydroxy-2,5-dioxohexanoate

> <ALOGPS_LOGP>
-1.14

> <JCHEM_LOGP>
-2.027202744333333

> <ALOGPS_LOGS>
-0.08

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
10.792721942209434

> <JCHEM_PKA_STRONGEST_ACIDIC>
2.5240306368417036

> <JCHEM_PKA_STRONGEST_BASIC>
-3.3278882311562272

> <JCHEM_POLAR_SURFACE_AREA>
134.96

> <JCHEM_REFRACTIVITY>
47.6498

> <JCHEM_ROTATABLE_BOND_COUNT>
5

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.73e+02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
2,5-diketo-D-gluconate

> <JCHEM_VEBER_RULE>
0

$$$$

HEADER    PROTEIN                                 13-AUG-12   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   13-AUG-12         0                                  
HETATM    1  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    3  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    4  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       0.000   0.000   0.000  0.00  0.00           C+0
HETATM    7  O   UNK     0       0.000   0.000   0.000  0.00  0.00           O+0
HETATM    8  O   UNK     0       0.000   0.000   0.000  0.00  0.00           O+0
HETATM    9  O   UNK     0       0.000   0.000   0.000  0.00  0.00           O+0
HETATM   10  O   UNK     0       0.000   0.000   0.000  0.00  0.00           O+0
HETATM   11  O   UNK     0       0.000   0.000   0.000  0.00  0.00           O+0
HETATM   12  O   UNK     0       0.000   0.000   0.000  0.00  0.00           O-1
HETATM   13  O   UNK     0       0.000   0.000   0.000  0.00  0.00           O+0
HETATM   14  H   UNK     0       0.000   0.000   0.000  0.00  0.00           H+0
HETATM   15  H   UNK     0       0.000   0.000   0.000  0.00  0.00           H+0
CONECT    1    2    7                                                       
CONECT    2    1    3    8                                                  
CONECT    3    2    4    9   14                                             
CONECT    4    3    5   10   15                                             
CONECT    5    4    6   11                                                  
CONECT    6    5   12   13                                                  
CONECT    7    1                                                            
CONECT    8    2                                                            
CONECT    9    3                                                            
CONECT   10    4                                                            
CONECT   11    5                                                            
CONECT   12    6                                                            
CONECT   13    6                                                            
CONECT   14    3                                                            
CONECT   15    4                                                            
MASTER        0    0    0    0    0    0    0    0   15    0   28    0
END

Synonyms

Value	Source
2,5-Diketogluconate	ChEBI
2-Dehydro-L-idonate	ChEBI
D-Threo-2,5-hexodiulosonate	ChEBI
2,5-Diketogluconic acid	Generator
2-Dehydro-L-idonic acid	Generator
D-Threo-2,5-hexodiulosonic acid	Generator
2,5-Diketo-D-gluconic acid	Generator
2,5-dioxo-D-Gluconate	MeSH

Molecular Formula

C₆H₇O₇

Average Mass

191.1156

Monoisotopic Mass

191.019177578

IUPAC Name

(3S,4S)-3,4,6-trihydroxy-2,5-dioxohexanoate

Traditional Name

2,5-diketo-D-gluconate

CAS Registry Number

53736-12-2

SMILES

[H][C@@](O)(C(=O)CO)[C@]([H])(O)C(=O)C([O-])=O

InChI Identifier

InChI=1S/C6H8O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h3-4,7,9-10H,1H2,(H,12,13)/p-1/t3-,4+/m1/s1

InChI Key

RXMWXENJQAINCC-DMTCNVIQSA-M

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as medium-chain keto acids and derivatives. These are keto acids with a 6 to 12 carbon atoms long side chain.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Keto acids and derivatives

Sub Class

Medium-chain keto acids and derivatives

Direct Parent

Medium-chain keto acids and derivatives

Alternative Parents

Substituents

Medium-chain keto acid
Beta-hydroxy acid
Acyloin
Alpha-keto acid
Beta-hydroxy ketone
Hydroxy acid
Monosaccharide
Alpha-hydroxy ketone
Secondary alcohol
Ketone
Polyol
Carboxylic acid
Carboxylic acid derivative
Monocarboxylic acid or derivatives
Alcohol
Primary alcohol
Carbonyl group
Organic oxygen compound
Hydrocarbon derivative
Organic oxide
Organooxygen compound
Organic anion
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

2-oxo monocarboxylic acid anion (CHEBI:11449 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	173 g/L	ALOGPS
logP	-1.1	ALOGPS
logP	-2	ChemAxon
logS	-0.08	ALOGPS
pKa (Strongest Acidic)	2.52	ChemAxon
pKa (Strongest Basic)	-3.3	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	7	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	134.96 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	47.65 m³·mol⁻¹	ChemAxon
Polarizability	15.11 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0006-0900000000-66697df72cf11dbf7f41	2015-09-15	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-03ec-7900000000-97ebe6ed711475246178	2015-09-15	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-03dl-9200000000-a963788665da60d07e0a	2015-09-15	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-00ko-7900000000-eb51687ff97b29540276	2015-09-15	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-052r-9400000000-5a948ab5e28d4d5a185b	2015-09-15	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0a4i-9000000000-60c5fc89ff115a2f2c2d	2015-09-15	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-20	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-20	View Spectrum

Chromatographic Retention Times and Retention Indices

Retention Times

Chromatography Type	Technique	Column	Deposition Date	Retention Time (s)
Liquid Chromatography	HILIC	Waters Acquity UPLC-BEH Amide column (eluted)	2025-10-23	173.3
Liquid Chromatography	HILIC	Accucore 150 Amide HILIC (eluted)	2025-10-23	122.8
Liquid Chromatography	Reversed-phase	Hypersil Gold 1.9 µm C18 (void)	2025-10-23	70.4
Liquid Chromatography	Reversed-phase	Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) (eluted)	2025-10-23	351.7
Liquid Chromatography	Reversed-phase	XBridge C18 3.5u 2.1x50 mm (eluted)	2025-10-23	267.7
Liquid Chromatography	Reversed-phase	Ascentis Express C18 (void)	2025-10-23	345.2
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (void)	2025-10-23	1076.4
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-23	463.2
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC (eluted)	2025-10-23	987.9
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	187.1
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-23	244.3
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-23	190.5
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-23	51.3
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-23	396.7
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-23	762.3
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (void)	2025-10-23	73.3
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (void)	2025-10-23	250.4
Liquid Chromatography	Reversed-phase	Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex (eluted)	2025-10-23	1058.9
Liquid Chromatography	Reversed-phase	Waters Atlantis T3 (2.1 x 150 mm, 5 um) (eluted)	2025-10-23	652.4

Retention Indices

Chromatography Type	Peak Label	SMILES	Stationary Phase	Deposition Date	Retention Index
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_1	C[Si](C)(C)O[C@H](C(=O)CO)[C@H](O)C(=O)C(=O)[O-]	standard non polar	2025-10-23	2175.43
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_2	C[Si](C)(C)OCC(=O)[C@@H](O)[C@H](O)C(=O)C(=O)[O-]	standard non polar	2025-10-23	2038.8
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_3	C[Si](C)(C)O[C@H](C(=O)C(=O)[O-])[C@H](O)C(=O)CO	standard non polar	2025-10-23	1964.08
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_4	C[Si](C)(C)OC(CO)=C(O)[C@H](O)C(=O)C(=O)[O-]	standard non polar	2025-10-23	1626.94
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_5	C[Si](C)(C)OC(C(=O)[O-])=C(O)[C@H](O)C(=O)CO	standard non polar	2025-10-23	1869.17
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_6	C[Si](C)(C)OC(=CO)[C@@H](O)[C@H](O)C(=O)C(=O)[O-]	standard non polar	2025-10-23	1439.07
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_7	C[Si](C)(C)OCC(=O)[C@@H](O[Si](C)(C)C)[C@H](O)C(=O)C(=O)[O-]	standard non polar	2025-10-23	2337.03
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_8	C[Si](C)(C)O[C@H](C(=O)CO)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard non polar	2025-10-23	1406.23
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_9	C[Si](C)(C)OC(CO)=C(O[Si](C)(C)C)[C@H](O)C(=O)C(=O)[O-]	standard non polar	2025-10-23	1843.76
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_10	C[Si](C)(C)OC(C(=O)[O-])=C(O)[C@H](O[Si](C)(C)C)C(=O)CO	standard non polar	2025-10-23	2398.4
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_11	C[Si](C)(C)OC(=CO)[C@@H](O[Si](C)(C)C)[C@H](O)C(=O)C(=O)[O-]	standard non polar	2025-10-23	2017.09
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_12	C[Si](C)(C)OCC(=O)[C@@H](O)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard non polar	2025-10-23	1785.28
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_13	C[Si](C)(C)OCC(O[Si](C)(C)C)=C(O)[C@H](O)C(=O)C(=O)[O-]	standard non polar	2025-10-23	2034.04
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_14	C[Si](C)(C)OCC(=O)[C@@H](O)C(O)=C(O[Si](C)(C)C)C(=O)[O-]	standard non polar	2025-10-23	1546.03
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_15	C[Si](C)(C)OC=C(O[Si](C)(C)C)[C@@H](O)[C@H](O)C(=O)C(=O)[O-]	standard non polar	2025-10-23	1787.16
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_16	C[Si](C)(C)OC(C(=O)[O-])=C(O[Si](C)(C)C)[C@H](O)C(=O)CO	standard non polar	2025-10-23	1226.92
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_17	C[Si](C)(C)OC(CO)=C(O)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard non polar	2025-10-23	1299.74
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_18	C[Si](C)(C)OC(=CO)[C@@H](O)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard non polar	2025-10-23	1849.0
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_19	C[Si](C)(C)OC(CO)=C(O)C(O)=C(O[Si](C)(C)C)C(=O)[O-]	standard non polar	2025-10-23	2222.52
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_20	C[Si](C)(C)OC(=CO)[C@@H](O)C(O)=C(O[Si](C)(C)C)C(=O)[O-]	standard non polar	2025-10-23	1921.61
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_21	C[Si](C)(C)OCC(=O)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard non polar	2025-10-23	1798.09
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_22	C[Si](C)(C)OCC(O[Si](C)(C)C)=C(O[Si](C)(C)C)[C@H](O)C(=O)C(=O)[O-]	standard non polar	2025-10-23	2531.05
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_23	C[Si](C)(C)OCC(=O)[C@@H](O[Si](C)(C)C)C(O)=C(O[Si](C)(C)C)C(=O)[O-]	standard non polar	2025-10-23	1906.95
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_24	C[Si](C)(C)OC=C(O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O)C(=O)C(=O)[O-]	standard non polar	2025-10-23	1867.67
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_25	C[Si](C)(C)OC(CO)=C(O[Si](C)(C)C)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard non polar	2025-10-23	1816.83
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_26	C[Si](C)(C)OC(C(=O)[O-])=C(O[Si](C)(C)C)[C@H](O[Si](C)(C)C)C(=O)CO	standard non polar	2025-10-23	2154.55
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_27	C[Si](C)(C)OC(=CO)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard non polar	2025-10-23	1751.13
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_28	C[Si](C)(C)OC(CO)=C(O[Si](C)(C)C)C(O)=C(O[Si](C)(C)C)C(=O)[O-]	standard non polar	2025-10-23	1950.84
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_29	C[Si](C)(C)OC(=CO)[C@@H](O[Si](C)(C)C)C(O)=C(O[Si](C)(C)C)C(=O)[O-]	standard non polar	2025-10-23	1960.73
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_30	C[Si](C)(C)OCC(O[Si](C)(C)C)=C(O)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard non polar	2025-10-23	1533.93
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_31	C[Si](C)(C)OCC(=O)[C@@H](O)C(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(=O)[O-]	standard non polar	2025-10-23	2115.44
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_32	C[Si](C)(C)OC=C(O[Si](C)(C)C)[C@@H](O)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard non polar	2025-10-23	2839.86
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_33	C[Si](C)(C)OCC(O[Si](C)(C)C)=C(O)C(O)=C(O[Si](C)(C)C)C(=O)[O-]	standard non polar	2025-10-23	1568.42
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_34	C[Si](C)(C)OC=C(O[Si](C)(C)C)[C@@H](O)C(O)=C(O[Si](C)(C)C)C(=O)[O-]	standard non polar	2025-10-23	1694.73
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_35	C[Si](C)(C)OC(CO)=C(O)C(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(=O)[O-]	standard non polar	2025-10-23	2661.5
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_36	C[Si](C)(C)OC(=CO)[C@@H](O)C(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(=O)[O-]	standard non polar	2025-10-23	1772.81
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_37	C[Si](C)(C)OCC(O[Si](C)(C)C)=C(O[Si](C)(C)C)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard non polar	2025-10-23	2047.46
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_38	C[Si](C)(C)OCC(=O)[C@@H](O[Si](C)(C)C)C(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(=O)[O-]	standard non polar	2025-10-23	1443.22
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_39	C[Si](C)(C)OC=C(O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard non polar	2025-10-23	1155.13
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_40	C[Si](C)(C)OCC(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(O)=C(O[Si](C)(C)C)C(=O)[O-]	standard non polar	2025-10-23	1985.29
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_41	C[Si](C)(C)OC=C(O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)C(O)=C(O[Si](C)(C)C)C(=O)[O-]	standard non polar	2025-10-23	2381.03
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_42	C[Si](C)(C)OC(CO)=C(O[Si](C)(C)C)C(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(=O)[O-]	standard non polar	2025-10-23	882.13
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_43	C[Si](C)(C)OC(=CO)[C@@H](O[Si](C)(C)C)C(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(=O)[O-]	standard non polar	2025-10-23	2299.26
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_44	C[Si](C)(C)OCC(O[Si](C)(C)C)=C(O)C(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(=O)[O-]	standard non polar	2025-10-23	1335.35
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_45	C[Si](C)(C)OC=C(O[Si](C)(C)C)[C@@H](O)C(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(=O)[O-]	standard non polar	2025-10-23	1660.79
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_46	C[Si](C)(C)OCC(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(=O)[O-]	standard non polar	2025-10-23	2026.3
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_47	C[Si](C)(C)OC=C(O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)C(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(=O)[O-]	standard non polar	2025-10-23	1402.64
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_1	C[Si](C)(C)O[C@H](C(=O)CO)[C@H](O)C(=O)C(=O)[O-]	standard polar	2025-10-23	1783.04
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_2	C[Si](C)(C)OCC(=O)[C@@H](O)[C@H](O)C(=O)C(=O)[O-]	standard polar	2025-10-23	2303.34
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_3	C[Si](C)(C)O[C@H](C(=O)C(=O)[O-])[C@H](O)C(=O)CO	standard polar	2025-10-23	2158.26
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_4	C[Si](C)(C)OC(CO)=C(O)[C@H](O)C(=O)C(=O)[O-]	standard polar	2025-10-23	2616.21
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_5	C[Si](C)(C)OC(C(=O)[O-])=C(O)[C@H](O)C(=O)CO	standard polar	2025-10-23	2549.76
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_6	C[Si](C)(C)OC(=CO)[C@@H](O)[C@H](O)C(=O)C(=O)[O-]	standard polar	2025-10-23	1612.48
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_7	C[Si](C)(C)OCC(=O)[C@@H](O[Si](C)(C)C)[C@H](O)C(=O)C(=O)[O-]	standard polar	2025-10-23	1865.04
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_8	C[Si](C)(C)O[C@H](C(=O)CO)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard polar	2025-10-23	2328.59
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_9	C[Si](C)(C)OC(CO)=C(O[Si](C)(C)C)[C@H](O)C(=O)C(=O)[O-]	standard polar	2025-10-23	2235.09
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_10	C[Si](C)(C)OC(C(=O)[O-])=C(O)[C@H](O[Si](C)(C)C)C(=O)CO	standard polar	2025-10-23	2063.97
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_11	C[Si](C)(C)OC(=CO)[C@@H](O[Si](C)(C)C)[C@H](O)C(=O)C(=O)[O-]	standard polar	2025-10-23	2099.64
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_12	C[Si](C)(C)OCC(=O)[C@@H](O)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard polar	2025-10-23	2060.01
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_13	C[Si](C)(C)OCC(O[Si](C)(C)C)=C(O)[C@H](O)C(=O)C(=O)[O-]	standard polar	2025-10-23	2066.74
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_14	C[Si](C)(C)OCC(=O)[C@@H](O)C(O)=C(O[Si](C)(C)C)C(=O)[O-]	standard polar	2025-10-23	2119.99
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_15	C[Si](C)(C)OC=C(O[Si](C)(C)C)[C@@H](O)[C@H](O)C(=O)C(=O)[O-]	standard polar	2025-10-23	2443.41
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_16	C[Si](C)(C)OC(C(=O)[O-])=C(O[Si](C)(C)C)[C@H](O)C(=O)CO	standard polar	2025-10-23	2090.54
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_17	C[Si](C)(C)OC(CO)=C(O)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard polar	2025-10-23	2084.44
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_18	C[Si](C)(C)OC(=CO)[C@@H](O)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard polar	2025-10-23	2619.45
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_19	C[Si](C)(C)OC(CO)=C(O)C(O)=C(O[Si](C)(C)C)C(=O)[O-]	standard polar	2025-10-23	1692.45
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_20	C[Si](C)(C)OC(=CO)[C@@H](O)C(O)=C(O[Si](C)(C)C)C(=O)[O-]	standard polar	2025-10-23	2273.6
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_21	C[Si](C)(C)OCC(=O)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard polar	2025-10-23	2134.44
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_22	C[Si](C)(C)OCC(O[Si](C)(C)C)=C(O[Si](C)(C)C)[C@H](O)C(=O)C(=O)[O-]	standard polar	2025-10-23	2189.84
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_23	C[Si](C)(C)OCC(=O)[C@@H](O[Si](C)(C)C)C(O)=C(O[Si](C)(C)C)C(=O)[O-]	standard polar	2025-10-23	1795.35
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_24	C[Si](C)(C)OC=C(O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O)C(=O)C(=O)[O-]	standard polar	2025-10-23	2385.11
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_25	C[Si](C)(C)OC(CO)=C(O[Si](C)(C)C)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard polar	2025-10-23	2922.34
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_26	C[Si](C)(C)OC(C(=O)[O-])=C(O[Si](C)(C)C)[C@H](O[Si](C)(C)C)C(=O)CO	standard polar	2025-10-23	2232.73
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_27	C[Si](C)(C)OC(=CO)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard polar	2025-10-23	1350.09
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_28	C[Si](C)(C)OC(CO)=C(O[Si](C)(C)C)C(O)=C(O[Si](C)(C)C)C(=O)[O-]	standard polar	2025-10-23	2628.98
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_29	C[Si](C)(C)OC(=CO)[C@@H](O[Si](C)(C)C)C(O)=C(O[Si](C)(C)C)C(=O)[O-]	standard polar	2025-10-23	2950.27
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_30	C[Si](C)(C)OCC(O[Si](C)(C)C)=C(O)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard polar	2025-10-23	1786.28
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_31	C[Si](C)(C)OCC(=O)[C@@H](O)C(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(=O)[O-]	standard polar	2025-10-23	2237.98
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_32	C[Si](C)(C)OC=C(O[Si](C)(C)C)[C@@H](O)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard polar	2025-10-23	2233.2
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_33	C[Si](C)(C)OCC(O[Si](C)(C)C)=C(O)C(O)=C(O[Si](C)(C)C)C(=O)[O-]	standard polar	2025-10-23	2296.04
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_34	C[Si](C)(C)OC=C(O[Si](C)(C)C)[C@@H](O)C(O)=C(O[Si](C)(C)C)C(=O)[O-]	standard polar	2025-10-23	2769.61
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_35	C[Si](C)(C)OC(CO)=C(O)C(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(=O)[O-]	standard polar	2025-10-23	2857.27
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_36	C[Si](C)(C)OC(=CO)[C@@H](O)C(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(=O)[O-]	standard polar	2025-10-23	2707.12
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_37	C[Si](C)(C)OCC(O[Si](C)(C)C)=C(O[Si](C)(C)C)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard polar	2025-10-23	2768.0
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_38	C[Si](C)(C)OCC(=O)[C@@H](O[Si](C)(C)C)C(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(=O)[O-]	standard polar	2025-10-23	1988.15
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_39	C[Si](C)(C)OC=C(O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)C(=O)C(=O)[O-]	standard polar	2025-10-23	1388.94
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_40	C[Si](C)(C)OCC(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(O)=C(O[Si](C)(C)C)C(=O)[O-]	standard polar	2025-10-23	1904.71
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_41	C[Si](C)(C)OC=C(O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)C(O)=C(O[Si](C)(C)C)C(=O)[O-]	standard polar	2025-10-23	951.178
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_42	C[Si](C)(C)OC(CO)=C(O[Si](C)(C)C)C(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(=O)[O-]	standard polar	2025-10-23	1800.07
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_43	C[Si](C)(C)OC(=CO)[C@@H](O[Si](C)(C)C)C(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(=O)[O-]	standard polar	2025-10-23	2117.03
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_44	C[Si](C)(C)OCC(O[Si](C)(C)C)=C(O)C(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(=O)[O-]	standard polar	2025-10-23	2596.8
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_45	C[Si](C)(C)OC=C(O[Si](C)(C)C)[C@@H](O)C(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(=O)[O-]	standard polar	2025-10-23	2014.31
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_46	C[Si](C)(C)OCC(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(=O)[O-]	standard polar	2025-10-23	2731.73
Gas Chromatography	2,5-Diketo-D-gluconate_TMS_47	C[Si](C)(C)OC=C(O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)C(O[Si](C)(C)C)=C(O[Si](C)(C)C)C(=O)[O-]	standard polar	2025-10-23	1634.63

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Feces

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Name	SMPDB/PathBank	Species
Ketogluconate Metabolism		Escherichia coli Pseudomonas aeruginosa Escherichia coli SMS-3-5 Escherichia coli UTI89 Escherichia coli 55989 Escherichia coli SE11 Mycobacterium marinum M Pseudomonas aeruginosa PA7 Acinetobacter sp. ADP1 Actinobacillus succinogenes 130Z Escherichia coli CFT073 Ochrobactrum anthropi Bacillus subtilis Pseudomonas stutzeri Klebsiella pneumoniae Bacillus cereus Pseudomonas fluorescens Pf-5 Streptomyces griseus subsp. griseus NBRC 13350 Mycobacterium tuberculosis CDC1551 Bacillus amyloliquefaciens Streptococcus pneumoniae Salmonella enterica Clostridium acetobutylicum ATCC 824 Staphylococcus aureus Haemophilus influenzae Haemophilus influenzae Rd KW20 Lactobacillus fermentum IFO 3956 Streptococcus pneumoniae TIGR4 Saccharopolyspora erythraea NRRL 2338 Streptomyces avermitilis MA-4680 Shewanella denitrificans OS217 Acidaminococcus fermentans DSM 20731 Acidaminococcus intestini RyC-MR95 Acinetobacter baumannii Anaerostipes caccae Anaerostipes hadrus Arcobacter butzleri RM4018 Bacillus cereus AH187 (F4810/72) Bacillus halodurans C-125 Alkalihalobacillus pseudofirmus OF4 Bacillus timonensis 10403023 Bacteroides caccae Bacteroides cellulosilyticus Bacteroides eggerthii Bacteroides fragilis Bacteroides fragilis 638R Bacteroides fragilis YCH46 Bacteroides ovatus Bacteroides stercoris Bacteroides stercoris ATCC 43183 Bacteroides thetaiotaomicron Bacteroides thetaiotaomicron VPI-5482 Bacteroides vulgatus Bacteroides xylanisolvens XB1A Bifidobacterium Bifidum Bifidobacterium adolescentis Bifidobacterium adolescentis ATCC 15703 Bifidobacterium bifidum BGN4 Bifidobacterium bifidum PRL2010 Bifidobacterium longum Bifidobacterium longum DJO10A Bifidobacterium longum NCC2705 Bifidobacterium longum subsp. longum JDM301 Bifidobacterium mongoliense DSM 21395 Bifidobacterium thermophilum RBL67 Blautia hansenii DSM 20583 Blautia obeum A2-162 Brevibacillus brevis NBRC 100599 Clostridium beijerinckii NCIMB 8052 Clostridium saccharolyticum Coprococcus catus GD/7 Dorea formicigenerans ATCC 27755 Enterococcus faecalis Eubacterium eligens ATCC 27750 Geobacter metallireducens Limosilactobacillus fermentum Lactobacillus reuteri Methanobrevibacter smithii Methanobrevibacter smithii ATCC 35061 Methylobacterium nodulans Ochrobactrum anthropi ATCC 49188 Ochrobactrum intermedium LMG 3301 Odoribacter splanchnicus DSM 20712 Parabacteroides distasonis Parabacteroides distasonis ATCC 8503 Parabacteroides goldsteinii dnLKV18 Ruminococcus torques L2-14 lactobacillus jensenii Pelobacter carbinolicus Spirochaeta thermophila Thermus thermophilus Comamonas testosteroni Burkholderia cepacia Pseudomonas fluorescens Pseudomonas mendocina Pseudomonas putida Pseudomonas syringae Xanthomonas campestris Bradyrhizobium japonicum Mesorhizobium loti Sinorhizobium meliloti Methylococcus capsulatus Moraxella catarrhalis Neisseria flavescens Neisseria gonorrhoeae Neisseria mucosa Acidiphilium cryptum Chromobacterium violaceum Citrobacter koseri Proteus mirabilis Shigella boydii Shigella dysenteriae Shigella flexneri Shigella sonnei Vibrio cholerae Vibrio vulnificus Bacteroides uniformis Desulfovibrio salexigens Acidithiobacillus ferrooxidans Cytophaga hutchinsonii Rhodopseudomonas palustris Chlorobium phaeobacteroides Leuconostoc mesenteroides Staphylococcus epidermidis Deinococcus radiodurans Streptococcus gordonii Streptococcus oralis Streptococcus sanguinis Enterococcus gallinarum Bacillus licheniformis Priestia megaterium Bacillus mycoides Bacillus pumilus Bacillus thuringiensis Moorella thermoacetica Clostridium kluyveri Lactobacillus plantarum Lactobacillus coryniformis Listeria monocytogenes Actinomyces viscosus Bifidobacterium angulatum Cellulomonas flavigena Corynebacterium diphtheriae Corynebacterium glutamicum Mycobacterium avium Desulfobacterium autotrophicum Methanosphaera stadtmanae Thermotoga neapolitana Roseobacter denitrificans Bifidobacterium pseudocatenulatum Staphylococcus lugdunensis Acidothermus cellulolyticus Neisseria subflava Staphylococcus saprophyticus Pelobacter propionicus Enterococcus avium Thiobacillus denitrificans Enterococcus casseliflavus Stenotrophomonas maltophilia Actinosynnema mirum Streptococcus cristatus Brachyspira pilosicoli Blautia hydrogenotrophica Acidimicrobium ferrooxidans Burkholderia vietnamiensis Sodalis glossinidius Streptococcus peroris Enterobacter cancerogenus Bacillus clausii Bacillus pseudofirmus Methanobrevibacter ruminantium Bacillus selenitireducens Achromobacter xylosoxidans Burkholderia multivorans Dorea longicatena Burkholderia cenocepacia Actinomyces urogenitalis Methylibium petroleiphilum Syntrophobacter fumaroxidans Citrobacter youngae Burkholderia ambifaria Ilyobacter polytropus Marvinbryantia formatexigens Anaerotruncus colihominis Alicycliphilus denitrificans Desulfovibrio magneticus Shewanella denitrificans Methylocella silvestris Bacteroides massiliensis Escherichia albertii Lactobacillus gastricus Lactobacillus antri Streptococcus pseudopneumoniae Bacteroides nordii Syntrophus aciditrophicus Bacteroides intestinalis Actinomyces oris Bacteroides fluxus Bacteroides oleiciplenus Bacteroides faecis Agrobacterium tumefaciens Bacteroides xylanisolvens Bifidobacterium breve Bifidobacterium catenulatum Blautia hansenii Clostridium beijerinckii Dorea formicigenerans Klebsiella variicola Lactococcus lactis Odoribacter splanchnicus Parabacteroides goldsteinii Streptococcus mitis Streptococcus parasanguinis Streptococcus suis Rothia dentocariosa Rothia mucilaginosa Barnesiella intestinihominis Achromobacter xylosoxidans A8 Acinetobacter baumannii SDF Acinetobacter baumannii ACICU Acinetobacter baumannii AB0057 Acinetobacter baumannii AB307-0294 Actinobacillus pleuropneumoniae serovar 5b str. L20 Actinobacillus pleuropneumoniae serovar 3 str. JL03 Actinobacillus pleuropneumoniae serovar 7 str. AP76 Agrobacterium tumefaciens str. C58 Bacillus cereus ATCC 10987 Bacillus megaterium QM B1551 Bacillus thuringiensis serovar konkukian str. 97-27 Bacillus licheniformis ATCC 14580 Bacillus clausii KSM-K16 Bacillus amyloliquefaciens FZB42 Bacillus pumilus SAFR-032 Bacillus cereus B4264 Bacillus cereus AH820 Bacillus cereus G9842 Bacillus cereus Q1 Priestia megaterium DSM 319 Bacillus subtilis subsp. spizizenii str. W23 Bacillus amyloliquefaciens DSM 7 Bifidobacterium animalis subsp. lactis AD011 Bradyrhizobium japonicum USDA 110 Citrobacter koseri ATCC BAA-895 Clostridium sp. SY8519 Corynebacterium aurimucosum ATCC 700975 Corynebacterium kroppenstedtii DSM 44385 Cronobacter sakazakii ATCC BAA-894 Delftia acidovorans SPH-1 Dyadobacter fermentans DSM 18053 Enterobacter cloacae subsp. cloacae ATCC 13047 Escherichia coli APEC O1 Escherichia coli E24377A Escherichia coli O127:H6 str. E2348/69 Escherichia coli UMN026 Escherichia fergusonii ATCC 35469 Escherichia coli ED1a Escherichia coli IAI39 Haemophilus influenzae 86-028NP Haemophilus influenzae PittGG Klebsiella pneumoniae subsp. pneumoniae MGH 78578 Kocuria rhizophila DC2201 Lactobacillus plantarum WCFS1 Lactobacillus reuteri DSM 20016 Lactobacillus reuteri SD2112 Lactococcus lactis subsp. lactis Il1403 Lactococcus lactis subsp. cremoris SK11 Lactococcus lactis subsp. cremoris MG1363 Laribacter hongkongensis HLHK9 Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 Lysinibacillus sphaericus C3-41 Mesorhizobium loti MAFF303099 Methanobrevibacter ruminantium M1 Methanosphaera stadtmanae DSM 3091 Methylobacterium radiotolerans JCM 2831 Methylobacterium populi BJ001 Micrococcus luteus NCTC 2665 Mobiluncus curtisii ATCC 43063 Mycobacterium avium subsp. paratuberculosis K-10 Mycobacterium avium 104 Neisseria gonorrhoeae FA 1090 Neisseria meningitidis MC58 Neisseria meningitidis Z2491 Neisseria meningitidis FAM18 Neisseria gonorrhoeae NCCP11945 Tropheryma whipplei str. Twist Escherichia coli 042 Acinetobacter calcoaceticus PHEA-2 Edwardsiella tarda FL6-60 Bifidobacterium animalis subsp. lactis CNCM I-2494 Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1 Proteus mirabilis HI4320 Pseudomonas putida KT2440 Pseudomonas fluorescens Pf0-1 Pseudomonas stutzeri A1501 Pseudomonas fluorescens SBW25 Pseudomonas putida GB-1 Rhizobium leguminosarum bv. viciae 3841 Rhizobium leguminosarum bv. trifolii WSM2304 Rhodococcus erythropolis PR4 Rothia mucilaginosa DY-18 Rothia dentocariosa ATCC 17931 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 Salmonella enterica subsp. enterica serovar Newport str. SL254 Salmonella enterica subsp. enterica serovar Heidelberg str. SL476 Salmonella enterica subsp. enterica serovar Agona str. SL483 Salmonella enterica subsp. enterica serovar Dublin str. CT02021853 Shigella sonnei Ss046 Shigella dysenteriae Sd197 Shigella flexneri 5 str. 8401 Spirosoma linguale DSM 74 Staphylococcus aureus subsp. aureus Mu50 Staphylococcus aureus subsp. aureus COL Staphylococcus aureus subsp. aureus MRSA252 Staphylococcus epidermidis RP62A Staphylococcus epidermidis ATCC 12228 Staphylococcus haemolyticus JCSC1435 Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 Staphylococcus aureus subsp. aureus NCTC 8325 Stenotrophomonas maltophilia K279a Stenotrophomonas maltophilia R551-3 Streptococcus pneumoniae D39 Streptococcus sanguinis SK36 Streptococcus gordonii str. Challis substr. CH1 Streptococcus pneumoniae Hungary19A-6 Streptococcus pneumoniae JJA Streptococcus oralis Uo5 Sulfolobus solfataricus P2 Vibrio parahaemolyticus RIMD 2210633 Yersinia enterocolitica subsp. enterocolitica 8081 Yersinia pseudotuberculosis IP 31758 Bacteroides cellulosilyticus DSM 14838 Bacteroides eggerthii 1_2_48FAA Bacteroides fluxus YIT 12057 Bacteroides graminisolvens Bacteroides graminisolvens DSM 19988 = JCM 15093 Bacteroides intestinalis DSM 17393 Bacteroides nordii CL02T12C05 Bacteroides oleiciplenus YIT 12058 Bacteroides ovatus ATCC 8483 Bacteroides pyogenes DSM 20611 = JCM 6294 Bacteroides uniformis ATCC 8492 Bacteroides xylanisolvens SD CC 1b Bacteroides sp. 1_1_14 Bacteroides sp. 1_1_30 Bacteroides sp. 2_1_22 Bacteroides sp. 2_2_4 Bacteroides sp. D2 Bacteroides sp. D20 Bacteroides sp. D22 Barnesiella intestinihominis YIT 11860 Odoribacter laneus YIT 12061 Paraprevotella clara YIT 11840 Paraprevotella xylaniphila YIT 11841 Parabacteroides johnsonii DSM 18315 Parabacteroides sp. D13 Bacteroides dorei DSM 17855 Spirosoma linguale Chlorobium limicola Beijerinckia indica Bradyrhizobium elkanii Methylobacterium mesophilicum Methylobacterium mesophilicum SR1.6/6 Rhizobium etli Azorhizobium caulinodans Xanthobacter autotrophicus Alcaligenes faecalis Burkholderia cepacia GG4 Lautropia mirabilis Lautropia mirabilis ATCC 51599 Laribacter hongkongensis Eikenella corrodens Eikenella corrodens ATCC 23834 Kingella oralis Kingella oralis ATCC 51147 Neisseria cinerea ATCC 14685 Neisseria elongata Neisseria elongata subsp. glycolytica ATCC 29315 Neisseria macacae Neisseria macacae ATCC 33926 Neisseria meningitidis Neisseria mucosa ATCC 25996 Neisseria subflava NJ9703 Nitrosospira multiformis Bilophila wadsworthia 3_1_6 Arcobacter butzleri Succinatimonas hippei Succinatimonas hippei YIT 12066 Cedecea davisae Cedecea davisae DSM 4568 Citrobacter amalonaticus Citrobacter amalonaticus Y19 Citrobacter freundii Citrobacter youngae ATCC 29220 Enterobacter hormaechei Escherichia albertii TW07627 Klebsiella aerogenes Salmonella Salmonella enterica subsp. enterica serovar Typhimurium Trabulsiella guamensis Trabulsiella guamensis ATCC 49490 Tatumella ptyseos Tatumella ptyseos ATCC 33301 Edwardsiella tarda Edwardsiella tarda ATCC 23685 Hafnia alvei Hafnia alvei ATCC 51873 Morganella morganii Morganella morganii subsp. morganii KT Providencia rustigianii DSM 4541 Providencia stuartii ATCC 25827 Serratia marcescens subsp. marcescens Db11 Yersinia enterocolitica Yersinia pestis Yersinia pseudotuberculosis Plesiomonas shigelloides 302-73 Actinobacillus pleuropneumoniae Haemophilus haemolyticus Haemophilus sputorum Acinetobacter pittii Acinetobacter johnsonii Acinetobacter johnsonii SH046 Acinetobacter junii SH205 Grimontia hollisae CIP 101886 Vibrio fluvialis Vibrio fluvialis PG41 Vibrio parahaemolyticus Vibrio mimicus Brachyspira pilosicoli B2904 Actinomyces naeslundii Actinomyces naeslundii str. Howell 279 Actinomyces urogenitalis DSM 15434 Actinomyces viscosus C505 Mobiluncus curtisii Trueperella pyogenes Bifidobacterium stercoris JCM 15918 Bifidobacterium angulatum DSM 20098 = JCM 7096 Bifidobacterium boum Bifidobacterium catenulatum DSM 16992 = JCM 1194 = LMG 11043 Bifidobacterium longum subsp. infantis CCUG 52486 Bifidobacterium mongoliense Bifidobacterium pseudocatenulatum DSM 20438 = JCM 1200 = LMG 10505 Bifidobacterium thermacidophilum Bifidobacterium thermophilum Corynebacterium amycolatum Corynebacterium aurimucosum Corynebacterium durum Corynebacterium durum F0235 Corynebacterium tuberculostearicum Corynebacterium tuberculostearicum SK141 Gordonia terrae C-6 Rhodococcus erythropolis Brevibacterium casei Brevibacterium casei S18 Brevibacterium linens Microbacterium oleivorans Kocuria palustris PEL Rothia aeria F0474 Cellulosimicrobium cellulans Tropheryma whipplei Propionibacterium Streptomyces avermitilis Thermomonospora curvata Olsenella profusa F0195 Bacillus altitudinis Bacillus infantis NRRL B-14911 Bacillus firmus DS1 Lysinibacillus sphaericus Listeria grayi Listeria grayi DSM 20601 Listeria monocytogenes 10403S Aneurinibacillus aneurinilyticus Aneurinibacillus aneurinilyticus ATCC 12856 Paenibacillus lactis 154 Enterococcus caccae ATCC BAA-1240 Enterococcus casseliflavus ATCC 12755 Enterococcus phoeniculicola ATCC BAA-412 Lactobacillus hilgardii DSM 20176 = ATCC 8290 Lactobacillus antri DSM 16041 Lactobacillus gastricus PS3 Lactobacillus mucosae LM1 Lactobacillus reuteri CF48-3A Lactobacillus reuteri MM4-1A Lactobacillus coryniformis subsp. coryniformis CECT 5711 Leuconostoc mesenteroides subsp. cremoris ATCC 19254 Weissella paramesenteroides Weissella paramesenteroides ATCC 33313 Streptococcus australis ATCC 700641 Streptococcus infantis ATCC 700779 Butyricicoccus pullicaecorum Butyricicoccus pullicaecorum 1.2 Pseudoramibacter alactolyticus ATCC 23263 Anaerostipes caccae DSM 14662 Blautia hydrogenotrophica DSM 10507 Blautia wexlerae Dorea longicatena DSM 13814 Clostridium asparagiforme DSM 15981 [Clostridium] bolteae ATCC BAA-613 Clostridium citroniae WAL-17108 [Clostridium] hylemonae DSM 15053 [Clostridium] symbiosum WAL-14163 [Ruminococcus] gnavus ATCC 29149 [Ruminococcus] lactaris ATCC 29176 [Ruminococcus] torques ATCC 27756 Anaerotruncus colihominis DSM 17241 Flavonifractor plautii ATCC 29863 Pseudoflavonifractor capillosus ATCC 29799 [Clostridium] leptum DSM 753 [Clostridium] innocuum 2959 Clostridium spiroforme [Clostridium] spiroforme DSM 1552 Acidaminococcus intestini Phascolarctobacterium succinatutens YIT 12067 Megasphaera elsdenii Streptomyces coelicolor A3(2) Bordetella pertussis Tohama I Bordetella parapertussis 12822 Ralstonia eutropha H16 Xanthomonas campestris pv. campestris str. ATCC 33913 Xanthomonas campestris pv. campestris str. B100 Xanthomonas campestris pv. campestris str. 8004 Vibrio cholerae M66-2 Vibrio cholerae O1 biovar El Tor str. N16961 Corynebacterium glutamicum ATCC 13032 Clostridioides difficile 630 Clostridioides difficile NAP08 Shewanella frigidimarina NCIMB 400 Bacillus cytotoxicus NVH 391-98 Bifidobacterium longum subsp. infantis Bifidobacterium longum subsp. longum Lachnoclostridium phytofermentans ISDg Streptococcus mitis B6 Streptococcus parasanguinis ATCC 15912 Streptococcus parasanguinis FW213 Streptococcus suis GZ1 Acidimicrobium ferrooxidans DSM 10331 Acidothermus cellulolyticus 11B Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 Alkaliphilus metalliredigens QYMF Amycolatopsis mediterranei U32 Anoxybacillus flavithermus WK1 Arthrobacter sp. FB24 Arthrobacter aurescens TC1 Arthrobacter chlorophenolicus A6 Bacillus selenitireducens MLS10 Beutenbergia cavernae DSM 12333 Bifidobacterium dentium Bd1 Catenulispora acidiphila DSM 44928 Cellulomonas flavigena DSM 20109 Clavibacter michiganensis subsp. michiganensis NCPPB 382 Clostridium kluyveri DSM 555 Clostridium kluyveri NBRC 12016 Conexibacter woesei DSM 14684 Corynebacterium jeikeium K411 Corynebacterium glutamicum R Corynebacterium urealyticum DSM 7109 Corynebacterium resistens DSM 45100 Deinococcus radiodurans R1 Deinococcus geothermalis DSM 11300 Deinococcus proteolyticus MRP Frankia alni ACN14a Frankia sp. EuI1c Geobacillus kaustophilus HTA426 Geobacillus thermodenitrificans NG80-2 Gordonia bronchialis DSM 43247 Intrasporangium calvum DSM 43043 Jonesia denitrificans DSM 20603 Kineococcus radiotolerans SRS30216 Kribbella flavida DSM 17836 Listeria innocua Clip11262 Listeria welshimeri serovar 6b str. SLCC5334 Macrococcus caseolyticus JCSC5402 Meiothermus ruber DSM 1279 Mycobacterium leprae TN Mycobacterium bovis AF2122/97 Mycobacterium ulcerans Agy99 Mycobacterium vanbaalenii PYR-1 Mycobacterium bovis BCG str. Pasteur 1173P2 Mycobacterium tuberculosis H37Ra Mycobacterium abscessus ATCC 19977 Mycobacterium leprae Br4923 Mycobacterium sp. Spyr1 Mycobacterium sp. JDM601 Mycobacterium canettii CIPT 140010059 Nakamurella multipartita DSM 44233 Natranaerobius thermophilus JW/NM-WN-LF Nocardia farcinica IFM 10152 Nocardioides sp. JS614 Corynebacterium diphtheriae NCTC 13129 Oceanobacillus iheyensis HTE831 Dictyoglomus turgidum DSM 6724 Bacillus tusciae DSM 2912 Thermobaculum terrenum ATCC BAA-798 Pseudonocardia dioxanivorans CB1190 Renibacterium salmoninarum ATCC 33209 Rhodococcus opacus B4 Rhodococcus jostii RHA1 Rhodococcus equi 103S Rubrobacter xylanophilus DSM 9941 Saccharomonospora viridis DSM 43017 Salinispora tropica CNB-440 Sanguibacter keddieii DSM 10542 Sphaerobacter thermophilus DSM 20745 Stackebrandtia nassauensis DSM 44728 Staphylococcus carnosus subsp. carnosus TM300 Streptococcus suis BM407 Streptomyces scabiei 87.22 Streptomyces violaceusniger Tu 4113 Streptosporangium roseum DSM 43021 Symbiobacterium thermophilum IAM 14863 Thermoanaerobacter sp. X514 Thermoanaerobacter pseudethanolicus ATCC 33223 Thermoanaerobacter italicus Ab9 Thermoanaerobacterium thermosaccharolyticum DSM 571 Thermobispora bispora DSM 43833 Thermomonospora curvata DSM 43183 Tsukamurella paurometabola DSM 20162 Xylanimonas cellulosilytica DSM 15894 Aspergillus nomiae NRRL 13137 Aspergillus novofumigatus Aspergillus novofumigatus IBT 16806 Aspergillus parasiticus SU-1 Aspergillus phoenicis Aspergillus ruber Aspergillus sclerotioniger Aspergillus glaucus Aspergillus aculeatus ATCC 16872 Aspergillus leporis Aspergillus niger ATCC 1015 Aspergillus oryzae RIB40 Aspergillus terreus NIH2624 Aspergillus wentii Aspergillus clavatus NRRL 1 Aspergillus fischeri NRRL 181 Aspergillus fumigatus A1163 Aspergillus fumigatus Af293 Aspergillus calidoustus Aspergillus nidulans FGSC A4 Aspergillus taichungensis Aspergillus tamarii Aspergillus thermomutatus Aspergillus tubingensis Aspergillus violaceofuscus Aspergillus viridinutans Penicillium brasilianum Penicillium brevicompactum Penicillium canescens Penicillium chermesinum Penicillium citrinum Penicillium concentricum Penicillium daleae Penicillium decumbens Penicillium griseofulvum Penicillium hordei Penicillium italicum Penicillium nalgiovense Penicillium oxalicum Penicillium polonicum Penicillium roqueforti FM164 Penicillium solitum Penicillium steckii Penicillium thymicola Penicillium vulpinum Verticillium alfalfae VaMs.102 Trichoderma arundinaceum Trichoderma asperellum Trichoderma atroviride IMI 206040 Trichoderma citrinoviride Trichoderma harzianum Trichoderma longibrachiatum Trichoderma parareesei Trichoderma reesei QM6a Trichoderma virens Trichoderma virens Gv29-8 Fusarium acutatum Fusarium fujikuroi IMI 58289 Fusarium mangiferae Fusarium nygamai Fusarium proliferatum ET1 Fusarium subglutinans Fusarium verticillioides 7600 Fusarium heterosporum Fusarium equiseti Fusarium oxysporum Fo5176 Fusarium oxysporum f. sp. lycopersici 4287 Fusarium austroamericanum Fusarium graminearum PH-1 Fusarium poae Fusarium pseudograminearum CS3096 Fusarium sporotrichioides Fusarium vanettenii Fusarium vanettenii 77-13-4 Fusarium tricinctum Paraburkholderia graminis C4D1M Schaalia odontolytica ATCC 17982 Schaalia turicensis ACS-279-V-Col4 Mycolicibacterium fortuitum subsp. fortuitum DSM 46621 = ATCC 6841 Rhodococcus hoagii ATCC 33707 Acidipropionibacterium acidipropionici ATCC 4875 Leuconostoc mesenteroides subsp. cremoris Klebsiella aerogenes KCTC 2190 Halanaerobium hydrogeniformans Acaryochloris marina MBIC11017 Acidiphilium cryptum JF-5 Acidiphilium multivorum AIU301 Acidithiobacillus ferrooxidans ATCC 23270 Acidobacterium capsulatum ATCC 51196 Acidovorax citrulli AAC00-1 Acidovorax sp. JS42 Acidovorax ebreus TPSY Aeromonas salmonicida subsp. salmonicida A449 Agrobacterium vitis S4 Agrobacterium radiobacter K84 Rhodoferax ferrireducens T118 Alicycliphilus denitrificans K601 Vibrio fischeri MJ11 Aliivibrio salmonicida LFI1238 Alkalilimnicola ehrlichii MLHE-1 Anabaena variabilis ATCC 29413 Anaeromyxobacter dehalogenans 2CP-C Anaeromyxobacter sp. Fw109-5 Anaeromyxobacter sp. K Anaeromyxobacter dehalogenans 2CP-1 Aquifex aeolicus VF5 Azorhizobium caulinodans ORS 571 Azotobacter vinelandii DJ Mannheimia succiniciproducens MBEL55E Beijerinckia indica subsp. indica ATCC 9039 Bordetella petrii DSM 12804 Bordetella avium 197N Brachyspira hyodysenteriae WA1 Brachyspira murdochii DSM 12563 Brachyspira pilosicoli 95/1000 Bradyrhizobium sp. ORS278 Bradyrhizobium sp. BTAi1 Brucella melitensis bv. 1 str. 16M Brucella abortus bv. 1 str. 9-941 Brucella ovis ATCC 25840 Brucella canis ATCC 23365 Brucella suis ATCC 23445 Brucella abortus S19 Brucella melitensis ATCC 23457 Brucella microti CCM 4915 Burkholderia mallei ATCC 23344 Burkholderia pseudomallei 1710b Burkholderia sp. 383 Burkholderia xenovorans LB400 Burkholderia ambifaria AMMD Burkholderia mallei NCTC 10229 Burkholderia pseudomallei 1106a Burkholderia vietnamiensis G4 Burkholderia cenocepacia MC0-3 Burkholderia ambifaria MC40-6 Burkholderia phymatum STM815 Burkholderia phytofirmans PsJN Burkholderia cenocepacia J2315 Burkholderia rhizoxinica HKI 454 Candidatus Koribacter versatilis Ellin345 Candidatus Pelagibacter ubique HTCC1062 Caulobacter crescentus CB15 Caulobacter crescentus NA1000 Caulobacter segnis ATCC 21756 Cellulophaga algicola DSM 14237 Cellvibrio japonicus Ueda107 Cellvibrio gilvus ATCC 13127 Chitinophaga pinensis DSM 2588 Chlorobium phaeobacteroides DSM 266 Chlorobium limicola DSM 245 Chloroflexus aurantiacus J-10-fl Chloroflexus aggregans DSM 9485 Chromohalobacter salexigens DSM 3043 Citrobacter rodentium ICC168 Colwellia psychrerythraea 34H Cronobacter turicensis z3032 Cupriavidus metallidurans CH34 Cupriavidus taiwanensis LMG 19424 Cupriavidus necator N-1 Cyanothece sp. ATCC 51142 Cyanothece sp. PCC 8801 Cyanothece sp. PCC 7424 Cytophaga hutchinsonii ATCC 33406 Deinococcus deserti VCD115 Desulfitobacterium hafniense Y51 Desulfitobacterium hafniense DCB-2 Desulfobacterium autotrophicum HRM2 Desulfomicrobium baculatum DSM 4028 Desulfovibrio magneticus RS-1 Desulfovibrio salexigens DSM 2638 Dickeya dadantii Ech703 Dickeya zeae Ech1591 Dickeya dadantii Ech586 Dickeya dadantii 3937 Dinoroseobacter shibae DFL 12 Edwardsiella ictaluri 93-146 Enterobacter sp. 638 Enterobacter cloacae SCF1 Erwinia tasmaniensis Et1/99 Erwinia amylovora CFBP1430 Erwinia billingiae Eb661 Ferrimonas balearica DSM 9799 Geobacter metallireducens GS-15 Geobacter uraniireducens Rf4 Gloeobacter violaceus PCC 7421 Gluconacetobacter diazotrophicus PAl 5 Gluconobacter oxydans 621H Haemophilus parasuis SH0165 Hahella chejuensis KCTC 2396 Haliangium ochraceum DSM 14365 Halorhodospira halophila SL1 Haloterrigena turkmenica DSM 5511 Halothermothrix orenii H 168 Herminiimonas arsenicoxydans Herpetosiphon aurantiacus DSM 785 Hydrogenobacter thermophilus TK-6 Hyphomonas neptunium ATCC 15444 Idiomarina loihiensis L2TR Ilyobacter polytropus DSM 2926 Isosphaera pallida ATCC 43644 Jannaschia sp. CCS1 Janthinobacterium sp. Marseille Klebsiella pneumoniae 342 Leadbetterella byssophila DSM 17132 Leifsonia xyli subsp. xyli str. CTCB07 Leptospira borgpetersenii serovar Hardjo-bovis JB197 Leptothrix cholodnii SP-6 Maricaulis maris MCS10 Marinobacter aquaeolei VT8 Marinomonas mediterranea MMB-1 Marinomonas posidonica IVIA-Po-181 Meiothermus silvanus DSM 9946 Methylibium petroleiphilum PM1 Methylobacillus flagellatus KT Methylobacterium chloromethanicum CM4 Methylobacterium nodulans ORS 2060 Methylobacterium extorquens AM1 Methylobacterium extorquens DM4 Methylocella silvestris BL2 Methylovorus glucosetrophus SIP3-4 Microbacterium testaceum StLB037 Microcystis aeruginosa NIES-843 Natrialba magadii ATCC 43099 Neisseria meningitidis alpha14 Neisseria lactamica 020-06 Nitrobacter winogradskyi Nb-255 Nitrobacter hamburgensis X14 Nitrosococcus oceani ATCC 19707 Nitrosomonas eutropha C91 Nitrosospira multiformis ATCC 25196 Candidatus Korarchaeum cryptofilum OPF8 Nostoc sp. PCC 7120 Nostoc punctiforme PCC 73102 Novosphingobium aromaticivorans DSM 12444 Bordetella bronchiseptica RB50 Xanthomonas axonopodis pv. citri str. 306 Nitrosomonas europaea ATCC 19718 Chromobacterium violaceum ATCC 12472 Thermus thermophilus HB27 Sodalis glossinidius str. 'morsitans' Magnetococcus sp. MC-1 Sorangium cellulosum 'So ce 56' Opitutus terrae PB90-1 Alteromonas macleodii str. 'Deep ecotype' Dictyoglomus thermophilum H-6-12 Gemmatimonas aurantiaca T-27 Thermus scotoductus SA-01 Rhodobacter capsulatus SB1003 Pantoea ananatis LMG 20103 Paracoccus denitrificans PD1222 Parvibaculum lavamentivorans DS-1 Pasteurella multocida subsp. multocida str. Pm70 Pectobacterium atrosepticum SCRI1043 Pectobacterium carotovorum subsp. carotovorum PC1 Pedobacter heparinus DSM 2366 Pelobacter carbinolicus DSM 2380 Pelobacter propionicus DSM 2379 Chlorobium luteolum DSM 273 Pelodictyon phaeoclathratiforme BU-1 Persephonella marina EX-H1 Petrotoga mobilis SJ95 Phenylobacterium zucineum HLK1 Photobacterium profundum SS9 Photorhabdus luminescens subsp. laumondii TTO1 Photorhabdus asymbiotica subsp. asymbiotica ATCC 43949 Pirellula staleyi DSM 6068 Planctomyces limnophilus DSM 3776 Polaromonas sp. JS666 Polaromonas naphthalenivorans CJ2 Prochlorococcus marinus subsp. pastoris str. CCMP1986 Prochlorococcus marinus str. AS9601 Prosthecochloris aestuarii DSM 271 Pseudoalteromonas haloplanktis TAC125 Pseudomonas syringae pv. tomato str. DC3000 Pseudomonas syringae pv. phaseolicola 1448A Pseudomonas syringae pv. syringae B728a Pseudomonas entomophila L48 Pseudomonas fulva 12-X Psychromonas ingrahamii 37 Ralstonia solanacearum GMI1000 Rhizobium etli CFN 42 Rhizobium etli CIAT 652 Rhizobium leguminosarum bv. trifolii WSM1325 Rhodopirellula baltica SH 1 Rhodopseudomonas palustris CGA009 Rhodopseudomonas palustris HaA2 Rhodopseudomonas palustris BisB5 Rhodospirillum centenum SW Rhodothermus marinus DSM 4252 Roseiflexus sp. RS-1 Roseiflexus castenholzii DSM 13941 Roseobacter denitrificans OCh 114 Roseobacter litoralis Och 149 Ruegeria pomeroyi DSS-3 Ruegeria sp. TM1040 Saccharophagus degradans 2-40 Salinibacter ruber DSM 13855 Salmonella enterica subsp. enterica serovar Paratyphi A str. Segniliparus rotundus DSM 44985 Shewanella oneidensis MR-1 Shewanella sp. ANA-3 Shewanella amazonensis SB2B Shewanella sp. W3-18-1 Shewanella baltica OS155 Shewanella loihica PV-4 Shewanella sediminis HAW-EB3 Shewanella pealeana ATCC 700345 Shewanella baltica OS195 Shewanella halifaxensis HAW-EB4 Shewanella woodyi ATCC 51908 Shewanella piezotolerans WP3 Shewanella violacea DSS12 Shigella flexneri 2a str. 301 Shigella boydii Sb227 Shigella boydii CDC 3083-94 Sinorhizobium meliloti 1021 Sinorhizobium medicae WSM419 Sphingobium japonicum UT26S Sphingomonas wittichii RW1 Sphingopyxis alaskensis RB2256 Spirochaeta thermophila DSM 6192 Synechococcus sp. CC9311 Synechococcus sp. WH 7803 Synechococcus sp. PCC 7002 Syntrophobacter fumaroxidans MPOB Syntrophus aciditrophicus SB Teredinibacter turnerae T7901 Thermocrinis albus DSM 14484 Thermomicrobium roseum DSM 5159 Thermotoga petrophila RKU-1 Thermotoga sp. RQ2 Thermotoga neapolitana DSM 4359 Tolumonas auensis DSM 9187 Variovorax paradoxus EPS Verminephrobacter eiseniae EF01-2 Vibrio vulnificus CMCP6 Vibrio vulnificus YJ016 Vibrio splendidus LGP32 Xanthobacter autotrophicus Py2 Xanthomonas oryzae pv. oryzae KACC10331 Xanthomonas campestris pv. vesicatoria str. 85-10 Xanthomonas oryzae pv. oryzae PXO99A Xenorhabdus bovienii SS-2004 Xenorhabdus nematophila ATCC 19061 Zunongwangia profunda SM-A87 Zymomonas mobilis subsp. pomaceae ATCC 29192 Sphingobacterium paucimobilis HER1398 Neisseria meningitidis serogroup C Atlantibacter hermannii NBRC 105704 Klebsiella michiganensis KCTC 1686 Chania multitudinisentens RB-25 Hungatella hathewayi DSM 13479 Veillonella seminalis ACS-216-V-Col6b

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference
MMDBr0019088	2,5-Diketo-D-gluconate	5-Keto-D-gluconate	Glyoxylate/hydroxypyruvate reductase B	Reduction	PathBank	31602464
MMDBr0019089	2,5-Diketo-D-gluconate	2-Dehydro-D-gluconate	2,5-diketo-D-gluconic acid reductase B	Reduction	PathBank	31602464

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria/Eubacteria	Proteobacteria	3	Human ; Human feces; Human feces; pleural fluid plaque; bal	Unknown
Bacteria	Actinobacteria	2
Bacteria	Proteobacteria	2	Human ; Human feces; Human feces; pleural fluid plaque; bal	Unknown

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified									HMDB

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

9548631

PDB ID

Not Available

ChEBI ID

11449

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

Wishart DS, Li C, Marcu A, Badran H, Pon A, Budinski Z, Patron J, Lipton D, Cao X, Oler E, Li K, Paccoud M, Hong C, Guo AC, Chan C, Wei W, Ramirez-Gaona M: PathBank: a comprehensive pathway database for model organisms. Nucleic Acids Res. 2020 Jan 8;48(D1):D470-D478. doi: 10.1093/nar/gkz861. [PubMed:31602464 ]
Bansal P, Morgat A, Axelsen KB, Muthukrishnan V, Coudert E, Aimo L, Hyka-Nouspikel N, Gasteiger E, Kerhornou A, Neto TB, Pozzato M, Blatter MC, Ignatchenko A, Redaschi N, Bridge A: Rhea, the reaction knowledgebase in 2022. Nucleic Acids Res. 2022 Jan 7;50(D1):D693-D700. doi: 10.1093/nar/gkab1016. [PubMed:34755880 ]

Showing metabocard for 2,5-Diketo-D-gluconate (MMDBc0029780)

MOL for #<Metabolite:0x00007f9ad81f2758>

3D MOL for #<Metabolite:0x00007f9ad81f2758>

3D SDF for #<Metabolite:0x00007f9ad81f2758>

3D-SDF for #<Metabolite:0x00007f9ad81f2758>

PDB for #<Metabolite:0x00007f9ad81f2758>

3D PDB for #<Metabolite:0x00007f9ad81f2758>

SMILES for #<Metabolite:0x00007f9ad81f2758>

INCHI for #<Metabolite:0x00007f9ad81f2758>

Structure for #<Metabolite:0x00007f9ad81f2758>

3D Structure for #<Metabolite:0x00007f9ad81f2758>