Microbial
Record Information
Version2.0
StatusDetected and Quantified
Creation Date2021-11-18 02:03:13 UTC
Update Date2025-11-05 17:13:04 UTC
Metabolite IDMMDBc0032120
Metabolite Identification
Common NameL-histidinol-phosphate
DescriptionL-histidinol-phosphate is a phosphoric acid derivative of L-histidinol and belongs to the class of amino acid metabolites involved in amino acid biosynthesis. Its chemical structure features a histidinol moiety phosphorylated at the hydroxyl group, which plays a pivotal role in the biosynthetic pathway of histidine, an essential amino acid. The enzyme HolPase is crucial for the dephosphorylation of L-histidinol-phosphate to L-histidinol, marking a significant step in histidine biosynthesis, often regarded as the last and most challenging enzyme to identify in this pathway due to its complex evolutionary background (PMID:40596842 ). Additionally, genetic complementation studies have indicated that the gene cg0910 encodes an essential L-histidinol-phosphate phosphatase (EC 3.1.3.15) in certain bacterial species, further underscoring the importance of this metabolite in the histidine biosynthetic pathway (PMID:16901339 ). Overall, L-histidinol-phosphate serves as a key intermediate in the synthesis of histidine, highlighting its relevance in both chemistry and biology.
Structure
Synonyms
ValueSource
L-Histidinol-phosphoric acidGenerator
Molecular FormulaC12H9ClO
Average Mass204.65
Monoisotopic Mass204.0341926
IUPAC Name5-chloro-2-phenylphenol
Traditional Name5-chloro-2-phenylphenol
CAS Registry NumberNot Available
SMILES
OC1=CC(Cl)=CC=C1C1=CC=CC=C1
InChI Identifier
InChI=1S/C12H9ClO/c13-10-6-7-11(12(14)8-10)9-4-2-1-3-5-9/h1-8,14H
InChI KeyLMUKIFZFZRTUIY-UHFFFAOYSA-N