MiMeDB: Showing metabocard for 2-MLCL(16:0/12:0(3-OH)/16:0/0:0) (MMDBc0060079)

Microbial

Human

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2023-01-28 18:57:05 UTC

Update Date

2025-10-07 20:20:54 UTC

Metabolite ID

MMDBc0060079

Metabolite Identification

Common Name

2-MLCL(16:0/12:0(3-OH)/16:0/0:0)

Description

2-MLCL(16:0/12:0(3-OH)/16:0/0:0) is a monolysocardiolipin (MLCL). Monolysocardiolipins have three fatty acid tails instead of the usual four found in cardiolipins. The fourth acyl chain, located at the R4 position, is missing in 2-MLCL species. MLCL occurs in eukaryotic cells as part of the metabolic cycle of mitochondrial lipids. Removal of one acyl chain from cardiolipin generates monolysocardiolipin (MLCL). MLCL has been used as an intermediate in the synthesis of spin-labeled cardiolipins to study interactions with mitochondrial enzymes. Because MLCL is implicated in lipid remodeling and apoptosis, it has been used to investigate interactions with various enzymes involved in these processes. There are two positional isomers of monolysocardiolipins: 1-MLCL, which lacks a fatty acid at position R1, and 2-MLCL, which lacks a fatty acid at position R4.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Molecular Formula

C₅₃H₁₀₂O₁₇P₂

Average Mass

1073.331

Monoisotopic Mass

1072.66032298

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

Not Available

InChI Identifier

Not Available

InChI Key

CKTIHSHUVZSOIM-WSZTXSGQSA-L

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Not Available

Predicted Properties

Not Available

Spectra

Not Available

Chromatographic Retention Times and Retention Indices

Retention Times

Chromatography Type	Technique	Column	Deposition Date	Retention Time (s)
Liquid Chromatography	HILIC	Waters Acquity UPLC-BEH Amide column (void)	2025-10-24	244.9
Liquid Chromatography	HILIC	Accucore 150 Amide HILIC (eluted)	2025-10-24	117.1
Liquid Chromatography	Reversed-phase	Hypersil Gold 1.9 µm C18 (eluted)	2025-10-24	1363.8
Liquid Chromatography	Reversed-phase	Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) (eluted)	2025-10-24	1867.1
Liquid Chromatography	Reversed-phase	XBridge C18 3.5u 2.1x50 mm (eluted)	2025-10-24	2102.1
Liquid Chromatography	Reversed-phase	Ascentis Express C18 (eluted)	2025-10-24	326.5
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (retained)	2025-10-24	6821.4
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-24	219.8
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC (eluted)	2025-10-24	285.1
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	1334.4
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-24	505.2
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	197.8
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-24	416.7
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-24	11.4
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (void)	2025-10-24	357.7
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-24	1282.3
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-24	879.9
Liquid Chromatography	Reversed-phase	Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex (eluted)	2025-10-24	3673.8
Liquid Chromatography	Reversed-phase	Waters Atlantis T3 (2.1 x 150 mm, 5 um) (eluted)	2025-10-24	3665.3

Retention Indices

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference
MMDBr0034387	CL(16:0/12:0(3-OH)/16:0/12:0(3-OH))	2-MLCL(16:0/12:0(3-OH)/16:0/0:0)	Cardiolipin-specific deacylase 1, mitochondrial	Deacylation	RHEA	34755880

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

Showing metabocard for 2-MLCL(16:0/12:0(3-OH)/16:0/0:0) (MMDBc0060079)

MOL for #<Metabolite:0x00005624c9d214e8>

3D MOL for #<Metabolite:0x00005624c9d214e8>

3D SDF for #<Metabolite:0x00005624c9d214e8>

3D-SDF for #<Metabolite:0x00005624c9d214e8>

PDB for #<Metabolite:0x00005624c9d214e8>

3D PDB for #<Metabolite:0x00005624c9d214e8>

SMILES for #<Metabolite:0x00005624c9d214e8>

INCHI for #<Metabolite:0x00005624c9d214e8>

Structure for #<Metabolite:0x00005624c9d214e8>

3D Structure for #<Metabolite:0x00005624c9d214e8>